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Found 365 clinical trials
Study of Nivolumab in Combination With 177Lu-girentuximab for Kidney Cancer

The purpose of this study is to see if the combination of 177Lu-girentuximab and nivolumab is a safe and effective treatment for advanced clear cell renal cell carcinoma/ccRCC that has the CAIX protein.

nivolumab
kidney cancer
systemic therapy
platelet count
carcinoma
  • 0 views
  • 24 Mar, 2022
  • 5 locations
Modi-1 in Breast, Head and Neck, Ovarian, or Renal Cancer (ModiFY)

The main objectives of this study are to assess the safety, tolerability, immunological activity, and preliminary efficacy of the Modi-1/Modi-1v vaccine, both as monotherapy and in combination with a checkpoint inhibitor (CPI) such as pembrolizumab or nivolumab (where these are standard of care in a non-neoadjuvant setting), in patients with …

measurable disease
breast cancer
nivolumab
chemoradiotherapy
pembrolizumab
  • 0 views
  • 26 May, 2022
  • 3 locations
Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT). The primary objective is to reduce the number of units of allogenic blood

cancer
nephrectomy
  • 0 views
  • 07 Aug, 2021
  • 3 locations
Aldesleukin and Pembrolizumab in Treating Patients With Advanced or Metastatic Kidney Cancer

This phase I trial studies the side effects and best dose of aldesleukin when given together with pembrolizumab in treating patients with kidney cancer that has spread to other parts of the body

measurable disease
aldesleukin
direct bilirubin
curative surgery
bevacizumab
  • 21 views
  • 13 Apr, 2022
  • 1 location
CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition (Cyto-KIK)

without any visible kidney cancer in their body at some point during the course of treatment.

nivolumab
tubal ligation
cabozantinib
kidney cancer
carcinoma
  • 42 views
  • 22 Apr, 2022
  • 2 locations
Preventing Toxicity in Renal Cancer Patients Treated With Immunotherapy Using Fecal Microbiota Transplantation (PERFORM)

Cancer immunotherapy has been largely adopted in oncology patient management in the last decade. The deep and long responses to immunotherapy have accelerated the approval of these drugs across multiple disease sites. However, these agents can also be toxic to patients, meaning, the patient will have to discontinue treatment and …

nivolumab
karnofsky performance status
kidney cancer
curative surgery
gilbert's syndrome
  • 22 views
  • 23 Apr, 2022
  • 1 location
Pamiparib and Temozolomide for the Treatment of Hereditary Leiomyomatosis and Renal Cell Cancer

and temozolomide may help treat patients with hereditary leiomyomatosis and renal cell cancer.

carcinoma
pet scan
neutrophil count
anticoagulants
serum bilirubin
  • 0 views
  • 04 Nov, 2021
  • 1 location
Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer

This phase I/II trial studies the side effects and best dose of pazopanib hydrochloride and bevacizumab and to see how well they work in treating patients with previously untreated kidney cancer

measurable disease
bevacizumab
24-hour urine protein
solid tumour
neutrophil count
  • 114 views
  • 27 May, 2022
  • 4 locations
Neoadjuvant Study With Combination Immuno-oncology for Primary Clear Cell Renal Cell Cancer (NESCIO)

The NESCIO-trial is a multicenter, randomized, open-label, three-arm phase II trial investigating different combinations of neoadjuvant immunotherapy in patients with primary, resectable, intermediate to high-risk, clear-cell renal cell carcinoma. In this trial patients will be randomized 1:1:1 to receive either 2 cycles of nivolumab 360mg every 3 weeks (arm A), …

primary tumor
carcinoma
programmed cell death 1 ligand 1
nivolumab
nephrectomy
  • 0 views
  • 24 May, 2022
  • 1 location
Clinical Study of CD70-targeted CAR-T Therapy for Advanced/Advanced Renal Cancer

This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with advanced/metastatic renal cell carcinoma, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.

measurable disease
carcinoma
renal function
renal function tests
metastatic renal cell carcinoma
  • 0 views
  • 11 Jul, 2022
  • 1 location