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Found 365 clinical trials
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of INCB099318 in select solid tumors.

  • 1 views
  • 23 Jul, 2022
  • 23 locations
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

dolutegravir
measurable disease
antiretroviral therapy
skin cancer
adrenaline
  • 6575 views
  • 19 Aug, 2022
  • 912 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

measurable disease
breast cancer
NTRK
lung cancer
tyrosine
  • 162 views
  • 21 Jul, 2022
  • 129 locations
First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours

The purpose of this study is to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of AZD8701 Alone and in Combination with Durvalumab (MEDI4736) in Adult Subjects with Select Advanced Solid Tumors

breast cancer
small lung
medi4736
triple negative breast cancer
lung carcinoma
  • 52 views
  • 29 Jul, 2022
  • 11 locations
Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

Background People with von Hippel-Lindau (VHL) can have problems with a variety of organs, such as the pancreas. The disease can cause tumors of the pancreas. This can result in life-threatening complications. Researchers want to learn more about these pancreatic tumors and how to better detect them. This may help …

neuroendocrine tumor
genetic testing
cyst
dotatate
ct scan
  • 0 views
  • 29 Jul, 2022
  • 1 location
SABR for Renal Tumors

Renal Cell Carcinoma (RCC) is the most common type of kidney cancer. The usual treatment for this type of cancer is surgery. Considering the most common patients are an average age of 65 and

carcinoma
metastasis
kidney cancer
cancer
renal neoplasm
  • 13 views
  • 01 Feb, 2022
  • 1 location
Pencil Beam Scanning in Patients With Renal Tumors

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

beam radiation
sarcoma
nephroblastoma
anaplasia
renal neoplasm
  • 15 views
  • 10 Aug, 2022
  • 1 location
Multiparametric MRI for Diagnosing Small Renal Tumors

differentiate benign from malignant renal tumors. The originality of this project lies in the opportunity to simultaneously assess the performance of mpMRI in diagnosing renal tumors in a routine clinical

cancer
nephrectomy
  • 0 views
  • 22 Aug, 2021
  • 18 locations
Percutaneous Cryoablation Versus Partial Nephrectomy for T1b Renal Tumor

The aim of our study is to assess the long-term oncological and functional outcomes of cryoablation for T1b renal tumors, as well as such important parameters as the patient's quality of life

nephrectomy
renal neoplasm
  • 0 views
  • 06 Aug, 2021
  • 1 location
Talazoparib and Axitinib for People With Previously Treated Advanced Kidney Cancer

Researchers are doing this study to find out if the combination of the drugs axitinib and talazoparib is a safe and effective treatment for people with your previously treated advanced kidney

measurable disease
hysterectomy
gilbert's syndrome
liver metastasis
programmed cell death 1 ligand 1
  • 7 views
  • 29 Jul, 2022
  • 7 locations