Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 382 clinical trials
Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer

A Phase 1/2, open label, multi-center study to evaluate the safety, efficacy and tolerability of KY1044 as single agent and in combination with anti-PD-L1 (atezolizumab) in adult patients with selected advanced malignancies, who are ineligible for or there are no available therapies known to confer a clinical benefit for their …

squamous cell carcinoma of head and neck
measurable disease
lung carcinoma
cancer
solid tumour
  • 89 views
  • 06 Jul, 2021
  • 11 locations
A Phase II Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma

This is a Phase II, multicenter, open-label, single arm, 2-stage study of tazemetostat 800 mg BID (twice daily) and 1600 mg QD (once daily). Subjects will be screened for eligibility within 21 days of the planned date of the first dose of tazemetostat and enrolled into one of 8 cohorts: …

measurable disease
solid tumour
cancer
cancer chemotherapy
monoclonal antibodies
  • 2 views
  • 19 Aug, 2021
  • 25 locations
ESTxENDS Trial: MN Substudy - Micronuclei in Buccal Epithelium a Surrogate Measure of Future Cancer Risk Induced by Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)

-related outcomes, in particular incident of mouth-, lung- and kidney- cancers.

nicotine replacement
cancer
tobacco smoke
cigarette smoke
  • 2 views
  • 25 Jan, 2021
  • 8 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

prednisone
gnrh
major surgery
metastatic disease
fgfr inhibitor azd4547
  • 6093 views
  • 07 Sep, 2021
  • 1028 locations
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

NTRK
measurable disease
lung carcinoma
cancer
lung cancer
  • 0 views
  • 15 Sep, 2021
  • 205 locations
A Phase 2 Study of NIR178 in Combination With PDR001 in Patients With Solid Tumors and Non-Hodgkin Lymphoma

The purpose of this phase 2 study is to evaluate the efficacy and safety of NIR178 in combination with PDR001 in multiple solid tumors and diffuse large B-cell lymphoma (DLBCL) and further explore schedule variations of NIR178 to optimize immune activation through inhibition of A2aR.

irinotecan
squamous cell carcinoma of head and neck
measurable disease
solid tumour
cancer
  • 230 views
  • 30 Jul, 2021
  • 28 locations
First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours

The purpose of this study is to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of AZD8701 Alone and in Combination with Durvalumab (MEDI4736) in Adult Subjects with Select Advanced Solid Tumors

medi4736
small lung
squamous cell carcinoma of head and neck
lung carcinoma
cancer
  • 52 views
  • 23 Aug, 2021
  • 12 locations
MR/TRUS Fusion Guided Prostate Biopsy

This study will determine if targeted (Magnetic Resonance (MR) / Ultrasound (US) fusion biopsy) plus conventional biopsy is superior to conventional biopsy alone in diagnosing subjects with prostate cancer.

prostate biopsy
MRI
transrectal ultrasound
cancer
anesthesia
  • 1 views
  • 23 Jan, 2021
  • 1 location
Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

Background People with von Hippel-Lindau (VHL) can have problems with a variety of organs, such as the pancreas. The disease can cause tumors of the pancreas. This can result in life-threatening complications. Researchers want to learn more about these pancreatic tumors and how to better detect them. This may help …

pet/ct scan
genetic testing
cyst
neuroendocrine tumor
ct scan
  • 0 views
  • 12 Sep, 2021
  • 1 location
SABR for Renal Tumors

Renal Cell Carcinoma (RCC) is the most common type of kidney cancer. The usual treatment for this type of cancer is surgery. Considering the most common patients are an average age of 65 and

metastasis
carcinoma
kidney cancer
cancer
renal neoplasm
  • 13 views
  • 21 Apr, 2021
  • 2 locations