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Found 369 clinical trials
A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

This study will compare the efficacy and safety of two doses of belzutifan in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The primary hypothesis is that the higher dose of belzutifan is superior to the standard dose in terms of objective response rate …

programmed cell death 1 ligand 1
vegf
measurable disease
carcinoma
tyrosine
  • 0 views
  • 20 May, 2021
  • 38 locations
Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Substudy 03A is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy 03A is to evaluate the safety and efficacy of experimental combinations of investigational agents in participants with advanced first …

major surgery
pembrolizumab
systemic therapy
lenvatinib
carcinoma
  • 0 views
  • 11 Jun, 2021
  • 19 locations
Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B)

Substudy 03B is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The larger study is the umbrella study (U03). The goal of substudy 03B is to evaluate the safety and efficacy of experimental combinations of investigational agents in participants with advanced second …

vegf
pembrolizumab
monoclonal antibodies
lenvatinib
tyrosine
  • 0 views
  • 04 Jun, 2021
  • 18 locations
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

This study will compare the efficacy and safety of belzutifan + lenvatinib versus cabozantinib in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy. The primary hypothesis is that belzutifan + lenvatinib is superior to cabozantinib in terms of progression-free survival or overall survival.

cabozantinib
clear cell renal cell carcinoma
programmed cell death 1 ligand 1
lenvatinib
measurable disease
  • 0 views
  • 10 Jun, 2021
  • 32 locations
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902) or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib Versus Pembrolizumab and Lenvatinib for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell carcinoma (ccRCC). The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is …

clear cell renal cell carcinoma
pembrolizumab
systemic therapy
lenvatinib
carcinoma
  • 0 views
  • 04 Jun, 2021
  • 22 locations
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)

The primary objective of this study is to compare belzutifan to everolimus with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and to compare everolimus with respect to overall survival (OS). The hypothesis is …

clear cell renal cell carcinoma
vegf
programmed cell death 1 ligand 1
kinase inhibitor
carcinoma
  • 168 views
  • 12 Jun, 2021
  • 177 locations
An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

The purpose of this study is to understand the metabolism of cancers involving the kidney, including renal cell carcinomas and urothelial cell carcinomas, and how kidney cancers use different

  • 0 views
  • 26 Jan, 2021
  • 1 location
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

nivolumab works in treating patients with renal cell cancer that has spread to other parts of the body.

interleukin-2
systemic therapy
monoclonal antibodies
tumor cells
sunitinib
  • 157 views
  • 12 Jun, 2021
  • 673 locations
A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

The purpose of this study is to evaluate MEDI5752 in adult subjects with advanced solid tumors, when administered as a single agent or combined with chemotherapy.

solid tumors
programmed cell death 1 ligand 1
cancer treatment
pembrolizumab
cancer
  • 160 views
  • 03 Jun, 2021
  • 36 locations
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium

Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to previous study, the neuroinflammation is the main reason both for POCD …

cancer
nephrectomy
prostatectomy
  • 45 views
  • 23 Jan, 2021
  • 5 locations