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Found 382 clinical trials
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation

The primary objective is to assess the activity and efficacy of pembrolizumab, a checkpoint inhibitor, in Veterans with metastatic castration-resistant prostate cancer (mCRPC) characterized by either mismatch repair deficiency (dMMR) or biallelic inactivation of CDK12 (CDK12-/-). The secondary objectives involve determining the frequency with which dMMR and CDK12-/- occur in …

  • 7 views
  • 16 Jul, 2021
  • 8 locations
Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorectal Gastroesophageal and Renal Cancers

This study will determine the pharmacodynamically-active dose of gevokizumab and the tolerable dose and preliminary efficacy of gevokizumab in combination with the standard of care anti-cancer therapy in patients with metastatic colorectal cancer, metastatic gastroesophageal cancer and metastatic renal cell carcinoma.

paclitaxel
folfiri regimen
metastasis
carcinoma
metastatic colorectal cancer
  • 74 views
  • 31 Aug, 2021
  • 48 locations
Renal Adjuvant MultiPle Arm Randomised Trial

RATIONALE: The current global standard of care after nephrectomy for localised RCC therefore remains active monitoring (i.e., observation by clinical and radiological means). 30-40% patients with initially localised RCC develop metastatic disease following nephrectomy. Need for adjuvant therapy is most marked in the high risk population where outcomes are predictably …

cancer
ct scan
metastasis
carcinoma
corticosteroids
  • 60 views
  • 25 Jan, 2021
  • 35 locations
89Zr-TLX250 for PET/CT Imaging of ccRCC- ZIRCON Study

89Zr-TLX250 is under clinical development as a diagnostic agent targeting clear cell renal cell carcinoma.

carcinoma
clear cell renal cell carcinoma
pet scan
nephrectomy
  • 21 views
  • 11 Aug, 2021
  • 40 locations
A Safety and Efficacy Study Evaluating CTX130 in Subjects With Relapsed or Refractory Renal Cell Carcinoma (COBALT-RCC)

This is a single-arm, open-label, multicenter, Phase 1 study evaluating the safety and efficacy of CTX130 in subjects with relapsed or refractory renal cell carcinoma.

karnofsky performance status
carcinoma
  • 29 views
  • 19 May, 2021
  • 7 locations
Anesthesia and Cancer Study: Renal Cell Carcinoma

This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

carcinoma
cancer
anesthesia
nephrectomy
  • 0 views
  • 25 Jan, 2021
  • 1 location
Pembrolizumab Plus Lenvatinib for First-line Advanced/Metastatic Non-clear Cell Renal Cell Carcinoma (1L nccRCC) (MK-3475-B61)

This study is being performed as a single-arm open-label study in order to rapidly provide information on the potential benefits of the combination of pembrolizumab and lenvatinib in participants with previously untreated advanced/metastatic non-clear cell renal cell carcinoma.

pembrolizumab
cancer
carcinoma
progressive disease
clear cell renal cell carcinoma
  • 0 views
  • 08 Sep, 2021
  • 56 locations
A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)

This is a randomized, Phase 3, double-blind, placebo-controlled study of pazopanib plus abexinostat versus pazopanib plus placebo in patients with locally advanced unresectable or metastatic renal cell carcinoma (RCC).

tyrosine
growth factor
metastasis
carcinoma
progressive disease
  • 27 views
  • 21 May, 2021
  • 45 locations
Yorkshire Kidney Screening Trial

Kidney cancer is the 8th most common cancer in Yorkshire. It has a poor survival rate, with only 6 out of 10 patients diagnosed with kidney cancer still alive after 5 years. This is partly

lung cancer
cancer
ct scan
kidney cancer
  • 0 views
  • 08 Sep, 2021
  • 1 location
Open vs Robotic Assisted Partial Nephrectomy

patients with intermediate to high complexity kidney tumors.

renal neoplasm
nephrectomy
  • 0 views
  • 27 Jan, 2021
  • 20 locations