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Found 377 clinical trials
Preliminary Evaluation of Uptake of [68Ga]P16-093 in Metastatic Prostate and Renal Cancer

An phase I study to evaluate the uptake of [68Ga]P16-093 in known or suspected metastatic prostate or renal cancer to establish the feasibility of using [68Ga]P16-093 to image PSMA expressing

prostatectomy
bone scan
brachytherapy
MRI Scan
pet/ct scan
  • 72 views
  • 11 May, 2022
  • 1 location
A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV)

This is a randomized, Phase 3, double-blind, placebo-controlled study of pazopanib plus abexinostat versus pazopanib plus placebo in patients with locally advanced unresectable or metastatic renal cell carcinoma (RCC).

carcinoma
measurable disease
growth factor
progressive disease
vegf
  • 27 views
  • 12 Feb, 2022
  • 1 location
[18F]PT2385 PET/CT in Patients With Renal Cell Carcinoma

This is an exploratory study to assess [18F]PT2385 Positron Emission Tomography/Computed Tomography (PET/CT) in patients with renal cell carcinoma (RCC). This is an open-label, nontherapeutic trial. The main objective is to correlate hypoxia-inducible factor-2alpha (HIF2) levels as determined by an investigational [18F]PT2385 PET/CT scan with the levels on subsequently obtained …

immunohistochemistry
carcinoma
primary tumor
pet scan
metastasis
  • 0 views
  • 03 Sep, 2021
  • 1 location
A Study of Belzutifan (MK-6482) as Monotherapy and in Combination With Lenvatinib (E7080/MK-7902) With or Without Pembrolizumab (MK-3475) in China Participants With Advanced Renal Cell Carcinoma (MK-6482-010)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles, and preliminary efficacy of belzutifan as monotherapy followed by belzutifan+lenvatinib combination therapy, as well as belzutifan combined with lenvatinib and pembrolizumab in China participants with advanced renal cell carcinoma.

carcinoma
measurable disease
serum pregnancy test
pembrolizumab
lenvatinib
  • 0 views
  • 30 Apr, 2022
  • 3 locations
Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma

This study will be comparing tivozanib in combination with nivolumab to tivozanib alone in subjects with advanced Renal Cell Carcinoma (RCC) who have had 1 or 2 prior lines of therapy, one of which was an Immune Checkpoint Inhibitor (ICI).

carcinoma
measurable disease
nivolumab
advanced renal cell carcinoma
  • 0 views
  • 03 Jun, 2022
  • 22 locations
Predictive Impact of MMP2 and MMP9 Levels for Patients With Metastatic Kidney Cancer Treated With Anti-angiogenic Agents

Prospective research of Matrix Metalloproteinases (MMP) 2 and 9 as predictive biomarkers in metastatic kidney cancer patients treated with 2 anti angiogenic agents (Sunitinib or Pazopanib).

sunitinib
cancer
pazopanib
metastatic renal cell carcinoma
  • 7 views
  • 25 Feb, 2022
  • 1 location
Evaluation of a Promising New Combination of Protein Kinase Inhibitors on Organotypic Cultures of Human Renal Tumors (COMBOREIN)

The investigators objective is to test the combination directly on organotypic cultures of tumors from patients after their excision in the Department of Urology and Renal Transplantation of the University Hospital of Grenoble and to compare their efficacy with that of currently selected treatments in the clinic. The population targeted …

carcinoma
cancer
nephrectomy
temsirolimus
pazopanib
  • 4 views
  • 04 Mar, 2022
  • 1 location
Protocol Active Surveillance Small Renal Masses (SRMs)

protocol in question, surgery or exit from the protocol) will be agreed between the patient and the patient. In the case of a positive renal biopsy for renal neoplasia, the patient may be a candidate for

hypercalcemia
renal neoplasm
nephrectomy
metastasis
  • 3 views
  • 27 Feb, 2022
  • 1 location
NeoVax Plus Ipilimumab in Renal Cell Carcinoma

This research study is evaluating a new type of Kidney Cancer vaccine called "Personalized NeoAntigen Cancer Vaccine"as a possible treatment for Kidney Cancer. The following intervention

carcinoma
neutrophil count
ipilimumab
clear cell renal cell carcinoma
cancer
  • 0 views
  • 08 Apr, 2022
Deferred Cytoreductive Nephrectomy in Synchronous Metastatic Renal Cell Carcinoma: The NORDIC-SUN-Trial

BACKGROUND: For synchronous metastatic renal cell carcinoma (RCC), surgical resection of the primary tumor in the presence of distant metastases has been the standard of therapy for select patients followed by systemic therapy. In the era of TKIs two randomized trials, CARMENA and SURTIME, have questioned the role and timing …

carcinoma
measurable disease
ipilimumab
metastatic renal cell carcinoma
nephrectomy
  • 0 views
  • 25 Jan, 2021
  • 3 locations