Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 25 clinical trials
Renal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes Study (Renal-HEIR)

further investigate the mechanisms of renal damage in youth with T2D, two optional procedures are included in the study: 1) kidney biopsy procedure and 2) induction of induced pluripotent stem cells

insulin sensitivity
hemoglobin a1c
fatty acids
renal failure
free fatty acid
  • 8 views
  • 24 Mar, 2022
  • 1 location
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes (IMPROVE-T2D)

procedures are included in the study prior to vertical sleeve gastrectomy: 1) kidney biopsy procedure and 2) induction of induced pluripotent stem cells (iPSCs) to assess morphometrics and genetic expression

insulin sensitivity
hemoglobin a1c
gastrectomy
renal failure
pancreatic failure
  • 97 views
  • 24 Mar, 2022
  • 1 location
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

who have been diagnosed with membranous nephropathy based on a kidney biopsy done within the preceding 24 months, and who have had excess levels of protein in the urine for at least 6 months based on

proteinuria
intravenous infusions
rituximab
blood proteins
angiotensin
  • 241 views
  • 10 May, 2022
  • 2 locations
Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus Nephritis (GLUREDLUP)

The aim of the study is to evaluate the efficacy of a therapeutic regimen which decreases glucocorticoid exposure compared with standard therapy in patients with proliferative lupus nephritis during remission induction by evaluating the histological and clinical remission.

steroid treatment
remission
mycophenolate
corticosteroids
rituximab
  • 0 views
  • 11 Mar, 2022
  • 1 location
A Study of REACT® in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT® injections given 3 months (+30 days) apart and delivered percutaneously into biopsied and non-biopsied contralateral kidneys in participants with T2DM and CKD.

diabetic nephropathy
type 2 diabetes mellitus
nephropathy
hemoglobin a1c
dialysis
  • 0 views
  • 10 May, 2022
  • 8 locations
Combined Blood Stem Cell and Kidney Transplant of One Haplotype Match Living Donor Pairs.

The Stanford Medical Center Program in Multi-Organ Transplantation and the Division of Bone marrow Transplantation are enrolling patients into a research study to determine if donor stem cells given after a living related one Haplotype match kidney transplantation will change the immune system such that immunosuppressive drugs can be completely …

immunosuppressants
rabbit atg
organ transplantation
immunosuppressive agents
kidney transplant
  • 26 views
  • 30 Sep, 2021
  • 2 locations
Treg Therapy in Subclinical Inflammation in Kidney Transplantation (TASK)

The purpose of this study is: To see if polyTregs can reduce inflammation in a transplanted kidney. To find out what effects, good or bad, polyTregs will have in the kidney recipient. To find out what effects, good or bad, taking everolimus after polyTregs will have in the kidney recipient.

mycophenolate
everolimus
mycophenolic acid
prednisone
immunosuppression
  • 35 views
  • 23 Feb, 2022
  • 6 locations
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent Probiotics in CKD Patients With PAD

Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD). Retention of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (PCS) and trimethylamine N-oxide (TMAO) during CKD is detrimental to endothelial and vascular function and can predispose to the development and …

  • 0 views
  • 15 Mar, 2021
  • 1 location
PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant

This is a phase III, multicenter, randomized, open label, clinical trial to test that hypothesis that plasmapheresis plus rituximab prior to kidney transplantation can prevent recurrent FSGS in children and adults.

hepatitis c
proteinuria
monoclonal antibodies
investigational drug
rituximab
  • 83 views
  • 12 Feb, 2022
  • 14 locations
Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function and compare it to the currently used treatment with the angiotensin converting enzyme inhibitor, …

mammogram
enzyme inhibitor
kidney biopsy
  • 17 views
  • 22 Mar, 2022
  • 1 location