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Found 27 clinical trials
Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion

This study is design to compare two different strategies aiming to lessen the degree of the ongoing process of allograft injury either by removing tacrolimus from the maintenance immunosuppressive protocol or by reducing tacrolimus dose. The primary goal is to assess the change in renal function at 6 and 12 …

renal impairment
kidney biopsy
immunosuppressive agents
tacrolimus
  • 11 views
  • 07 Nov, 2020
  • 1 location
Impact of Envarsus XR on Kidney Biopsy Subclinical Rejection and Blood Immunologic Profile

This will be a single center, prospective, open-label, randomized, controlled trial comparing Envarsus XR to twice-daily tacrolimus. The targeted population will be patients with end stage renal disease listed for primary solitary kidney transplant. Transplant Surgery is not part of the study.

nephropathy
kidney transplant
tacrolimus
  • 4 views
  • 17 Mar, 2021
  • 1 location
Low Energy Shockwave Therapy (LE-SWT): A Novel Treatment for Chronic Kidney Disease

-ethylenediaminetetraacetic acid (EDTA) renal clearance remains stable or increases in treated patients. Furthermore, kidney biopsy should show no signs of damage to the tissue and possibly neo-vascularization. In this

renal failure
tubular
diabetes
kidney biopsy
nephropathy
  • 226 views
  • 23 Jan, 2021
  • 1 location
Renal HEIR Study: Renal Hemodynamics Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes Study

further investigate the mechanisms of renal damage in youth with T2D, two optional procedures are included in the study: 1) kidney biopsy procedure and 2) induction of induced pluripotent stem cells

hyperglycemia
renal failure
insulin
glycated hemoglobin
insulin sensitivity
  • 8 views
  • 25 Jan, 2021
  • 1 location
Impact of Metabolic Surgery on Pancreatic Renal and Cardiovascular Health in Youth With Type 2 Diabetes

procedures are included in the study prior to vertical sleeve gastrectomy: 1) kidney biopsy procedure and 2) induction of induced pluripotent stem cells (iPSCs) to assess morphometrics and genetic expression

renal failure
insulin
glycated hemoglobin
insulin sensitivity
glomerular filtration rate
  • 97 views
  • 25 Jan, 2021
  • 1 location
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

who have been diagnosed with membranous nephropathy based on a kidney biopsy done within the preceding 24 months, and who have had excess levels of protein in the urine for at least 6 months based on

swelling
angiotensin
cyclosporin
mammogram
blood test
  • 236 views
  • 28 Jul, 2021
  • 2 locations
Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients

Maraviroc (MVC) is a type of HIV medicine called a CCR5 inhibitor. This study will evaluate the safety and tolerability of MVC in HIV-infected adults receiving a kidney transplant.

opportunistic infection
kidney transplant
hiv-1 rna measurement
HIV Infection
hiv antibody
  • 20 views
  • 22 Jan, 2021
  • 10 locations
Combined Blood Stem Cell and Kidney Transplant of One Haplotype Match Living Donor Pairs.

The Stanford Medical Center Program in Multi-Organ Transplantation and the Division of Bone marrow Transplantation are enrolling patients into a research study to determine if donor stem cells given after a living related one Haplotype match kidney transplantation will change the immune system such that immunosuppressive drugs can be completely …

immunosuppressive agents
rabbit atg
kidney transplant
immunosuppressants
organ transplantation
  • 26 views
  • 24 Jan, 2021
  • 2 locations
A Study of a Renal Autologous Cell Therapy (REACT) in Patients With Chronic Kidney Disease (CKD) From Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).

A PHASE 1, OPEN-LABEL SAFETY, TOLERABILITY, AND EARLY EFFICACY STUDY OF A RENAL AUTOLOGOUS CELL THERAPY (REACT) IN PATIENTS WITH CHRONIC KIDNEY DISEASE FROM CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT (CAKUT) (REGEN-004)

nephropathy
clopidogrel
  • 0 views
  • 28 May, 2021
  • 6 locations
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent Probiotics in CKD Patients With PAD

Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD). Retention of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (PCS) and trimethylamine N-oxide (TMAO) during CKD is detrimental to endothelial and vascular function and can predispose to the development and …

  • 0 views
  • 15 Mar, 2021
  • 1 location