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Found 24 clinical trials
A Phase 3 Randomized Controlled Study of Renal Autologous Cell Therapy (REACT®) in Subjects With Type 2 Diabetes and Chronic Kidney Disease (REGEN-006)

The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT® injections given 3 months (+30 days) apart and delivered percutaneously into biopsied and non-biopsied contralateral kidneys in participants with T2DM and CKD.

type 2 diabetes mellitus
glycosylated hemoglobin
diabetes
dialysis
diabetic nephropathy
  • 0 views
  • 21 Oct, 2022
  • 18 locations
A Phase 2, Open-Label, Single-Arm, Cohort Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Sparsentan Treatment in Pediatric Subjects With Selected Proteinuric Glomerular Diseases (EPPIK)

To evaluate the safety, efficacy and tolerability of sparsentan oral suspension and assess changes in proteinuria after once-daily dosing over the 108-week treatment period.

mammogram
glomerular filtration rate
kidney biopsy
corticosteroids
proteinuria
  • 1 views
  • 11 Oct, 2022
  • 26 locations
Per-protocol Repeat Kidney Biopsy in Incident Cases of Lupus Nephritis (REBIOLUP)

Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Among people living with SLE, 35-60% will develop LN during the course of the disease. This complication is one of the factors that contribute to deterioration of the renal function. Some centres perform kidney biopsies …

prednisone
calcineurin inhibitors
angiotensin
nephritis
kidney function tests
  • 0 views
  • 07 Jul, 2022
  • 1 location
Renal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes Study (Renal-HEIR)

further investigate the mechanisms of renal damage in youth with T2D, two optional procedures are included in the study: 1) kidney biopsy procedure and 2) induction of induced pluripotent stem cells

diabetes
renal hypoxia
renal failure
diabetic ketoacidosis
glomerular filtration rate
  • 9 views
  • 24 Mar, 2022
  • 1 location
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes (IMPROVE-T2D)

procedures are included in the study prior to vertical sleeve gastrectomy: 1) kidney biopsy procedure and 2) induction of induced pluripotent stem cells (iPSCs) to assess morphometrics and genetic expression

diabetes
aortic stiffness
gastrectomy
renal failure
sleeve gastrectomy
  • 97 views
  • 24 Mar, 2022
  • 1 location
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

who have been diagnosed with membranous nephropathy based on a kidney biopsy done within the preceding 24 months, and who have had excess levels of protein in the urine for at least 6 months based on

active treatment
intravenous infusions
angiotensin
rituximab
mammogram
  • 243 views
  • 21 Oct, 2022
  • 2 locations
Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus Nephritis (GLUREDLUP)

The aim of the study is to evaluate the efficacy of a therapeutic regimen which decreases glucocorticoid exposure compared with standard therapy in patients with proliferative lupus nephritis during remission induction by evaluating the histological and clinical remission.

prednisolone
systemic lupus erythematosus
mycophenolate
rituximab
remission
  • 0 views
  • 11 Mar, 2022
  • 1 location
PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplant

This is a phase III, multicenter, randomized, open label, clinical trial to test that hypothesis that plasmapheresis plus rituximab prior to kidney transplantation can prevent recurrent FSGS in children and adults.

kidney transplant
hepatitis c
obesity
antibiotics
rituximab
  • 102 views
  • 12 Feb, 2022
  • 14 locations
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent Probiotics in CKD Patients With PAD

Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD). Retention of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (PCS) and trimethylamine N-oxide (TMAO) during CKD is detrimental to endothelial and vascular function and can predispose to the development and …

  • 0 views
  • 15 Mar, 2021
  • 1 location
Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 Glomerulopathy

The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function and compare it to the currently used treatment with the angiotensin converting enzyme inhibitor, …

kidney biopsy
mammogram
enzyme inhibitor
  • 17 views
  • 22 Mar, 2022
  • 1 location