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Found 39 clinical trials
Study Of Intraductal Carboplatin In Women With Ductal Carcinoma In Situ (DCIS)

: pharmacokinetics, extent of disease on MRI and mammogram, histopathological assessment of DCIS, and biomarker measurement of Ki-67, TUNEL and G-actin.

neutrophil count
core needle biopsy
mammogram
carcinoma in situ
  • 46 views
  • 07 Nov, 2020
  • 2 locations
GE-148-002: A Phase 2 Open-label Single-Center Study to Assess GE-148 (18F) Injection PET Imaging to Detect Localized Prostate Cancer

Background: - GE-148 (18F) is a new drug that is designed to attach to prostate cancer cells. Researchers are interested in combining the drug with a small amount of radioactive material to allow prostate cancer lesions to appear more clearly on imaging scans. Researchers are also interested in determining whether …

  • 36 views
  • 08 Nov, 2020
  • 1 location
Study of Everolimus as Maintenance Therapy for Metastatic NEC With Pulmonary or Gastroenteropancreatic Origin

Cisplatin and Etoposide is the standard of care in NEC originating from the gastro-intestinal tract and lung, based on retrospective studies. Nevertheless the prognosis of this group of patients is still poor with median survival of less than 20 months. Everolimus is an mammilian target of rapamycin (mTOR) inhibitor that …

serum bilirubin
liver metastasis
metastasis
renal function
etoposide
  • 0 views
  • 23 Jan, 2021
  • 5 locations
Carboplatin Intensified Chemotherapy for TRIple NEgative Breast Cancer(CITRINE)

This is a prospective, single center, randomized, open-labled stage III clinical trial comparing the efficacy and safety of anthracyclin followed by weekly paclitaxel versus dose-dense anthracyclin followed by weekly paclitaxel versus dose-dense anthracyclin followed by weekly paclitaxel combined with carboplatin for high-risk, triple-negative early breast cancer.

epirubicin
HER2
erbb2
breast cancer
paclitaxel
  • 19 views
  • 23 Jan, 2021
  • 1 location
Comparative Study for the Degree of Biological Changes After Short-term 2 Weeks and 4 Weeks Preoperative Endocrine Therapy in Luminal Breast Cancer

(e.g., 2 weeks or 4 weeks) preoperative hormone therapy. Ki-67 is most commonly used among these markers. In contrast to the absolute value, the degree of Ki-67 changes which consider the baseline

HER2
hormone therapy
breast cancer
EGFR
cancer
  • 1 views
  • 22 Jan, 2021
  • 1 location
PersonaLized neoAdjuvant Strategy ER Positive and HER2 Negative Breast Cancer TO Increase BCS Rate

chemotherapy or neoadjuvant endocrine therapy using tools of nodal status, Ki-67, and multigene assay(Mammaprint)

HER2
breast-conserving surgery
erbb2
metastasis
hormone therapy
  • 0 views
  • 24 Jan, 2021
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

and surgery. This study is designed to assess whether tumor proliferation, as measured by the natural log expression of Ki-67 staining of breast tumor cells, is reduced following approximately

breast cancer
cancer
invasive breast cancer
breast surgery
ki-67
  • 12 views
  • 22 Jan, 2021
Personalized CAPTEM Radiopeptide Therapy of Advanced Non-resectable Neuroendocrine Cancer

-entero-pancreatic neuroendocrine tumors, GEP-NET, (G1, G2), in selected cases with high proliferation index (Ki-67> 20%, usually below 55%), NETG3, with overexpression of somatostatin receptor (SSTR

who 2017
somatostatin
radionuclide therapy
progressive disease
cancer
  • 5 views
  • 26 Jan, 2021
  • 1 location
Anastrozole Palbociclib Trastuzumab and Pertuzumab in Her-positive Her2-positive Metastatic Breast

response in an unbiased manner to see if this correlates with inhibition of Ki-67 and phosphorylated retinoblastoma expression as well as evaluate for potential mechanisms of resistance.

HER2
breast cancer
gene amplification
anastrozole
cancer
  • 38 views
  • 24 Jan, 2021
  • 4 locations
Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer

This early phase I trial studies how well abemaciclib and letrozole work in treating patients with endometrial cancer and determines whether there are changes in patients' cancer cell biomarkers (a genetic feature or specific protein) for cell growth before and after treatment. Antihormone therapy with aromatase inhibitors, such as letrozole, …

  • 2 views
  • 23 Jan, 2021
  • 2 locations