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Found 27 clinical trials
Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus Host Disease

Background Chronic Graft Versus Host Disease (cGVHD) can occur after a person has had a stem cell or bone marrow transplant. In cGVHD, the donor cells attack the recipient s body. Researchers want to see if a drug called ibruntinib can block one of the proteins that lead to the …

bone marrow transplant
acute graft-versus-host disease
neutrophil count
beclomethasone
ibrutinib
  • 0 views
  • 28 Feb, 2021
  • 2 locations
Maintenance Treatment Versus Observation in Elderly Patients With PCNS Lymphoma

Hypothesis Our hypothesis is that maintenance chemotherapy will prolong complete remission obtained after a standard induction chemotherapy with an acceptable toxicity in the elderly. Rationale Treatment of the elderly is challenging, indeed age over 60 is associated both with a poor prognosis and a high risk of treatment induced neurotoxicity …

primary cerebral lymphoma
rituximab
temozolomide
methotrexate
neurotoxicity
  • 23 views
  • 23 Jan, 2021
Protein Phosphatase 2A Inhibitor in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

gliosarcoma
recurrent disease
oligodendroglioma
renal function test
recurrent glioblastoma
  • 22 views
  • 27 Jan, 2021
  • 1 location
Carboplatin and Bevacizumab for Recurrent Ependymoma

The goal of this clinical research study is to learn if the combination of bevacizumab and carboplatin can help to control recurrent pendymoma. The safety of this drug combination will also be studied....

tumor progression
karnofsky performance status
interferon
ependymoma
cytotoxic agents
  • 0 views
  • 24 Jan, 2021
  • 2 locations
Study of Baricitinib a JAK1/2 Inhibitor in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Background Chronic graft versus host disease (cGVHD) can affect people who had a hematopoietic stem cell transplant using donor cells. It is often fatal. It is usually treated with high doses of steroids. But that helps only about half the people in the long term. Researchers want to see if …

jak inhibitors
neutrophil count
cell transplantation
corticosteroids
cancer
  • 23 views
  • 28 Feb, 2021
  • 1 location
Alvelestat (MPH966) an Oral Neutrophil Elastase Inhibitor in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Background Bronchiolitis obliterans syndrome (BOS) is a complication people can experience after hematopoietic stem cell transplant. It usually affects people with chronic graft versus host disease (cGVHD). This occurs when donor stem cells attack the cells of the person who received them. BOS reduces airflow and oxygen levels in the …

  • 35 views
  • 27 Feb, 2021
  • 1 location
Randomized Trial to Evaluate Accelerated Radiotherapy in Locally Advanced Carcinoma of Nasopharynx

The present study is designed as a two arm randomized trial to evaluate the impact of accelerated radiotherapy delivered by image guided radiotherapy with rapid arc technique in carcinoma nasopharynx. The study will evaluate a pure acceleration schedule of 6 fractions per week with concurrent chemotherapy and without any radiotherapy …

chemoradiotherapy
carcinoma
karnofsky performance status
  • 0 views
  • 26 Jan, 2021
  • 1 location
131I-IPA and Concurrent XRT in Recurrent GBM

A multi-centre, open-label, single-arm, dose-finding phase I/II study to evaluate safety, tolerability, dosing schedule, and preliminary efficacy of carrier-added 4-L-[131I]iodo-phenylalanine (131I-IPA), administered as single or repetitive injections in patients with recurrent glioblastoma multiforme (GBM), concomitantly to 2nd line external radiation therapy (XRT) - IPAX-1

temozolomide
recurrent glioblastoma
methionine
karnofsky performance status
beam radiation
  • 21 views
  • 25 Jan, 2021
  • 6 locations
Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study

The gamma knife radiosurgical thalamotomy to treat many movement disorders is recently becoming a new and well defined treatment paradigm. The CyberKnife if compared to the frame-based radiosurgery, is a pain free procedure which offers the advantage of a better patient's compliance by avoiding local anaesthesia and the discomfort due …

  • 0 views
  • 24 Jan, 2021
  • 1 location
EfiKroniK Research Program: Physical Exercise for People With Chronic Pathologies

Clinical objectives: estimate the common effect of the EfiKroniK physical exercise program for people with a set of Chronic diseases (solid cancers, hematological, schizophrenia and COPD), expressed in terms of functional capacity, quality of life and others results, regarding the standardized intervention of healthy habits 'Prescribe Healthy Living 'PVS. Implementation …

corticosteroids
cancer
smoking cessation
lymphoma
psychosis
  • 0 views
  • 25 Jan, 2021
  • 1 location