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Found 18 clinical trials
Myeloma XIV: Frailty-adjusted Therapy in Transplant Non-Eligible Patients With Newly Diagnosed Multiple Myeloma

validation of a novel frailty risk score (UK-MRA Myeloma Risk Profile - MRP), usefulness of Karnofsky Performance Status (PS), and association of molecular subgroups with response, PFS and OS.

dexamethasone
lenalidomide
  • 0 views
  • 23 Jun, 2021
  • 109 locations
WHOle Brain Irradiation or STEreotactic Radiosurgery for Five or More Brain Metastases (WHOBI-STER)

years, Karnofsky Performance Status (KPS) 70, life expectancy > 3 months, histological confirmation of primary tumor, with controlled or controllable extracranial disease, baseline Montreal

  • 0 views
  • 25 May, 2021
  • 4 locations
Pilot Phase 2 Study Whole Brain Radiation Therapy With Simultaneous Integrated Boost for Patients With Brain Metastases

This trial is a pilot, Phase 2, sequential two-cohort study designed to test two de-escalated whole brain radiation therapy (WBRT) dose levels and assess their ability to maintain acceptable in-brain distant control. The WBRT dose would decrease as the study moves forward, both in terms of absolute value and equivalent …

whole-brain radiotherapy
metastasis
solid tumor
  • 20 views
  • 10 Mar, 2022
  • 3 locations
Study to Evaluate Ibudilast and TMZ Combo Treatment in Newly Diagnosed and Recurrent Glioblastoma

Part 1 is an open-label, single-arm, dose escalation study of MN-166 (ibudilast) and temozolomide (TMZ) combination treatment. Evaluate safety and tolerability of ibudilast (MN-166) and TMZ combination treatment for 1 cycle (28 days); determine dosage in dose-finding study. Part 2 will evaluate efficacy of fixed-dose MN-166 (ibudilast) and TMZ combination …

gliadel
karnofsky performance status
gliosarcoma
measurable disease
glioblastoma multiforme
  • 13 views
  • 12 May, 2022
  • 1 location
A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas). (ImproveCodel)

Oligodendrogliomas in the novel edition of the Central Nervous System (CNS) World Health Organization (WHO) classification are now molecularly defined by isocitrate dehydrogenase (IDH)1 or IDH2 mutations and 1p/19q co-deletion. The prognosis of these molecularly defined tumors is to be determined in new series since survival data from older histology-based …

probe
IDH2
tumor progression
lomustine
temozolomide
  • 0 views
  • 06 May, 2022
  • 9 locations
Study of Decompensated Alcoholic Cirrhosis Treatment by Stem Cells

The main purpose of this study is to evaluate the safety and tolerance of umbilical cord mesenchymal stem cells (UCMSCs) in patients with decompensated alcoholic cirrhosis, and to provide dose basis for subsequent clinical study design. We will also explore the possible mechanism of UCMSCs in the treatment of decompensated …

liver disease
prothrombin
alcoholic cirrhosis
meld score
hepatitis
  • 0 views
  • 12 Mar, 2022
  • 1 location
Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus Host Disease

Background Chronic Graft Versus Host Disease (cGVHD) can occur after a person has had a stem cell or bone marrow transplant. In cGVHD, the donor cells attack the recipient s body. Researchers want to see if a drug called ibruntinib can block one of the proteins that lead to the …

budesonide
immunosuppressive agents
ibrutinib
beclomethasone
immunosuppression
  • 0 views
  • 15 May, 2022
  • 2 locations
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2

Background COVID-19 can cause problems in different parts of the body. For most people, it causes fevers or trouble breathing. Some people might not recover all the way. Researchers want to see if 2 treatments can help with people who have recovered from COVID-19 but still have symptoms ( Long-Haul …

  • 0 views
  • 10 May, 2022
  • 1 location
Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

platelet count
oligodendroglioma
gliosarcoma
glioblastoma multiforme
astrocytoma
  • 22 views
  • 13 May, 2022
  • 1 location
Role of Repeat Resection in Recurrent Glioblastoma

Patients with recurrent Glioblastoma (GBM) are commonly presented to surgeons, along with the question of whether or not to re-resect the recurrence. There is no Level 1 evidence to support a role for repeat surgery in this context, but a multitude of observational research suggests that repeat surgery may improve …

  • 0 views
  • 21 Apr, 2022