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Found 6 clinical trials
Assessing An Oral Janus Kinase Inhibitor AZD4205 as Monotherapy in Patients Who Have PTCL (JACKPOT8)

This is a multinational, non-randomized, open-label, Phase 1/2 clinical study to evaluate the safety, tolerability and anti-tumor efficacy of AZD4205 as monotherapy in patients with peripheral T cell lymphoma (PTCL), who have relapsed from or are refractory/intolerant to standard systemic treatment. Phase 1 part: Around 20~40 patients will be subsequently …

systemic therapy
t-cell lymphoma
peripheral t-cell lymphoma
measurable disease
  • 0 views
  • 30 May, 2021
  • 22 locations
Safety of Tofacitinib an Oral Janus Kinase Inhibitor in Primary Sjogren's Syndrome

Background An autoimmune disease is one in which the immune system attacks a person s own body. Sjogren's syndrome (SS) is an autoimmune disease. It often involves multiple systems and organs of the body. Researchers are trying to find new, more effective and safe treatments for SS. Objective To evaluate …

autoimmune disease
tofacitinib
  • 0 views
  • 08 Jul, 2021
  • 1 location
Advanced Therapeutics in Rheumatoid Arthritis (RA)

This study will evaluate the retention rates of two advanced therapies, Tumour Necrosis Factor (TNF) and Janus kinase inhibitor (JAK) in the treatment of adults with Rheumatoid Arthritis (RA

tumor necrosis factor
methotrexate
leflunomide
etanercept
hydroxychloroquine
  • 13 views
  • 23 Jan, 2021
  • 1 location
Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

In this trial, the investigators will begin to explore the possibility that, as in mice, janus kinase inhibitor 1 (JAK1) inhibition with haploidentical-hematopoietic cell transplantation (HCT

graft versus host disease
myeloablative conditioning
hodgkin's disease
leukapheresis
blast cells
  • 0 views
  • 25 Jan, 2021
  • 1 location
Evaluate the Efficacy and Safety of Topical SHR0302 Ointment in Patients With Mild-to-Moderate Atopic Dermatitis

This is a Randomized, Double-blind, Vehicle-Controlled, Seamless and Adaptive-designed Phase II/III Study to Evaluate the Efficacy and Safety of Topical SHR0302 Ointment in Adult and Adolescent Patients with Mild-to-Moderate Atopic Dermatitis. It will consist of phase II and phase III parts, phase II will be a dose-ranging part and phase …

  • 0 views
  • 29 Jan, 2021
  • 21 locations
Clinical Trial to Evaluate Efficacy of 3 Types of Treatment in Patients With Pneumonia by COVID-19

In absence of vaccine and medications specifically designed to treat SARS-CoV-2 disease, identifying treatment options is critical at this time to control the disease outbreak. For this, we have designed a phase II trial of efficacy and safety with 3 branches of different combinations of treatment to identify which is …

lopinavir/ritonavir
hydroxychloroquine
pneumonia
SARS
  • 0 views
  • 18 Feb, 2021
  • 1 location