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Found 42 clinical trials
Ph 2 Maintenance Trial: Ixazomib vs Ixazomib-Lenalidomide for MM Patients

This is a randomized, Phase 2 study involving two arms evaluating the efficacy and safety of ixazomib alone and the combination of both ixazomib and lenalidomide as maintenance therapy for

  • 0 views
  • 26 Jan, 2021
  • 1 location
Pomalidomide Ixazomib and Dexamethasone With or Without Intensification by Cyclophosphamide in Relapsed or Refractory Multiple Myeloma

The study is designed as a multicenter, non-randomized, Phase II trial with one treatment arm. A total of 82 patients of both genders and older than 18 years with relapsed/refractory multiple myeloma are planned to be included in the study. After the first 6 patients will have finished the first …

pomalidomide
platelet count
neutrophil count
lenalidomide
alkylating agents
  • 2 views
  • 25 Jan, 2021
  • 18 locations
Study of SubQ Dara With Dose-Attenuated Bortezomib Lenalidomide Dexamethasone in Elderly NDMM

This is a single center, open-label, phase 2 study in elderly (age 70) subjects with newly diagnosed multiple myeloma who are transplant ineligible. Subjects will receive subcutaneous daratumumab, dose-attenuated bortezomib, revlimid, and dexamethasone until confirmed disease progression, discontinuation of study treatment due to unacceptable drug toxicity, or other reasons. Throughout …

  • 1 views
  • 28 Jan, 2021
  • 1 location
Daratumumab-bortezomib-dexamethasone (Dara-VCd) vs Bortezomib-Thalidomide-Dexamethasone (VTd) Then Maintenance With Ixazomib (IXA) or IXA-Dara

-VCd) versus the association of bortezomib, thalidomide and dexamethasone (VTd) as pre transplant induction and post transplant consolidation, followed by maintenance with ixazomib alone or in

bone marrow procedure
serum calcium
measurable disease
velcade
thalidomide
  • 60 views
  • 24 Jan, 2021
  • 5 locations
Selinexor and Backbone Treatments of Multiple Myeloma Patients

: Selinexor + dexamethasone + lenalidomide (SRd) in NDMM Arm 8: Selinexor + dexamethasone + ixazomib (SNd) Arm 9: Selinexor + dexamethasone + pomalidomide + elotuzumab (SPEd) Arm

carfilzomib
refractory multiple myeloma
measurable disease
lenalidomide
monoclonal antibodies
  • 50 views
  • 07 May, 2021
  • 24 locations
Daratumumab Thalidomide and Dexamethasone in Relapse and/or Refractory Myeloma

myeloma in the last couple of years, including, Elotuzumab, Panobinostat, Ixazomib, carfilzomib and Pomalidomide. However, most of these drugs either do not have good single agent activity or still

  • 81 views
  • 22 Jan, 2021
  • 3 locations
Ixazomib + Pomalidomide + Dexamethasone In MM

This is a Phase I/II study using the combination of twice weekly ixazomib plus pomalidomide and dexamethasone in relapsed and or refractory multiple myeloma (RRMM) patients.

refractory multiple myeloma
measurable disease
pomalidomide
pomalyst
platelet count
  • 0 views
  • 25 Feb, 2021
Ixazomib and Dexamethasone Versus Ixazomib Dexamethasone and Lenalidomide Randomized With NFKB2 Rearrangement

This randomized phase II trial studies how well ixazomib and dexamethasone or ixazomib, dexamethasone, and lenalidomide work based on the presence of the rearrangement of a gene called nuclear

measurable disease
hysterectomy
platelet count
lenalidomide
cell transplantation
  • 0 views
  • 28 Jan, 2021
  • 4 locations
Trial of Ixazomib for Kaposi Sarcoma

This phase II trial studies how well ixazomib works in treating patients with Kaposi sarcoma. Ixazomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth

  • 0 views
  • 08 Apr, 2021
  • 2 locations
Daratumumab Ixazomib and Dexamethasone in AL Amyloidosis

This phase I trial studies the side effects and best dose of daratumumab, ixazomib, and dexamethasone in treating participants with amyloid light chain amyloidosis. Monoclonal antibodies, such

  • 128 views
  • 23 Feb, 2021
  • 2 locations