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Found 14 clinical trials
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis

The purpose of this pilot study is to explore wither ivacaftor in refractory CRS patients will demonstrate safety and tolerability; restore CFTR-mediated Cl- secretions as measured by EDSPD

cavities
ct scan
rhinosinusitis
ivacaftor
  • 6 views
  • 15 Jul, 2022
  • 1 location
Impact of Rifabutin on the Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor

This is a prospective, single-center, fixed-sequence, nonrandomized, open-label study in healthy adults to investigate the impact of rifabutin on the pharmacokinetics of trikafta.

Accepts healthy volunteers
  • 0 views
  • 26 May, 2022
  • 1 location
The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor

The study is a Phase 2 Study to establish the safety and efficacy of a drug called Ivacaftor (VX-770) in patients with chronic obstructive pulmonary disease (COPD), chronic bronchitis, and

bronchitis
diabetes
bronchodilator
a 10
vx-770
  • 140 views
  • 09 Apr, 2022
  • 1 location
Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER) (RECOVER)

RECOVER is a prospective, multicenter observational study designed to measure the real world clinical effectiveness of elexacaftor, tezacaftor and ivacaftor triple combination therapy (Kaftrio

tezacaftor
spirometry
ivacaftor
elexacaftor
fibrosis
  • 52 views
  • 31 May, 2022
  • 7 locations
Description of the Short-term Effects of KAFTRIO® by Continuous Monitoring With the PHEAL-CR-K Application in Real Life in Patients With Cystic Fibrosis Eligible for KAFTRIO® Treatment (PHEAL-KAFTRIO)

arrival of the KAFTRIO® triple therapy (ivacaftor/tezacaftor/elexacaftor). Clinical studies on this triple therapy demonstrate significant improvements in FEV (forced vital capacity) and also very rapid

tezacaftor
orkambi
sweat test
ivacaftor
elexacaftor
  • 0 views
  • 10 Aug, 2022
Personalized Theratyping Trial

The purpose of this study is to explore the use of off-label CFTR modulators that may affect CFTR function in patients with CFTR mutations that are not currently approved for these drugs.

cftr modulators
  • 1 views
  • 18 Sep, 2022
  • 1 location
Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials (Nof1)

The purpose of this study is to validate and utilize a personalized medicine approach to identify potential treatments with current FDA approved CFTR modifiers for non-approved CF gene mutations. The study will perform ex vivo testing of CFTR function and current marketed CFTR modulating drugs on expanded nasal cells at …

tezacaftor
cftr gene
tobramycin
ivacaftor
nasal potential difference
  • 0 views
  • 18 May, 2022
  • 1 location
Effect of Losartan in Cystic Fibrosis (CF)-NIH Grant #133240

The goal of this study is to execute a small clinical proof of concept trial: To examine the effects of losartan on mucociliary clearance (MCC) in patients not eligible for CFTR rescue therapies

fibrosis
oximetry
pulse oximetry
  • 0 views
  • 22 Mar, 2022
  • 1 location
Mutation-specific Therapy for the Long QT Syndrome

Novel therapy for the Long QT Syndrome based on the mechanism of action of the disease-causing mutations Long QT syndrome type 2 (LQT2) accounts for ~ 35% of all LQTS cases and is difficult to manage, as beta-blockers frequently fail to provide full protection. Most LQT2 patients (pts) have a …

electrocardiogram
atrial flutter
beta blockers
holter monitor
myocarditis
  • 0 views
  • 01 Sep, 2021
  • 1 location
Trikafta in Cystic Fibrosis Patients

This clinical study will enroll 42 participants without the F508del mutation, carrying partial function or N1303K mutations not approved for Trikafta, and who are not expected to be approved for CFTR modulator treatment in the immediate future. Each participant will be given Trikafta for approximately four weeks. The study researchers …

forced expiratory volume
cftr gene
neonatal screening
sweat test
nasal potential difference
  • 8 views
  • 27 Apr, 2022
  • 3 locations