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Found 15 clinical trials
Combination Chemotherapy With or Without Filgrastim Before Surgery High-Dose Chemotherapy and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma

. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Combining isotretinoin and monoclonal antibodies may kill

vincristine
melphalan
monoclonal antibodies
etoposide
high dose chemotherapy
  • 46 views
  • 07 Nov, 2020
  • 15 locations
Observation Combination Chemotherapy Radiation Therapy and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. An autologous stem cell transplant may …

vincristine
iobenguane
melphalan
etoposide
doxorubicin
  • 30 views
  • 07 Nov, 2020
  • 28 locations
Effects of Isotretinoin on CYP2D6 Activity

Specific Aim: To investigate if isotretinoin (13-cis-retinoic acid) administration decreases CYP2D6 activity in adolescent patients.

  • 0 views
  • 22 Jan, 2021
  • 1 location
  • 20 views
  • 07 Nov, 2020
  • 1 location
High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

therapy followed by peripheral blood stem cell rescue, radiotherapy to the site of the primary tumour and immunotherapy (R4 randomization - isotretinoin and ch14.18/CHO (Dinutuximab beta, Qarziba

vincristine
melphalan
etoposide
high-risk neuroblastoma
doxorubicin
  • 288 views
  • 26 Jan, 2021
  • 126 locations
Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking …

vincristine
iobenguane
melphalan
etoposide
high-risk neuroblastoma
  • 66 views
  • 31 Jul, 2021
  • 104 locations
Weekly Isotretinoin Therapy Study

antibiotic resistance. The efficacy of daily to twice daily dosed isotretinoin, an oral vitamin A derivative, for treatment of severe acne has been well established. The purpose of this study is to determine

  • 0 views
  • 15 Mar, 2021
  • 1 location
A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris

Acne vulgaris is a common disease of both males and females, usually manifesting initially during adolescence. The use of retinoic acid analogues such as adapalene, tazarotene and isotretinoin

  • 0 views
  • 11 Jul, 2021
  • 2 locations
Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Acne Vulgaris

conventional dose of oral isotretinoin for treatment of moderate or severe acne vulgaris. The hypothesis is that the painless ALA- PDT will be equally or more efficacious as oral isotretinoin, and taking

aminolevulinic acid
isotretinoin
photodynamic therapy
  • 35 views
  • 26 Jan, 2021
  • 1 location
Treatment With Dinutuximab Sargramostim (GM-CSF) and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)

This phase II trial studies if dinutuximab, GM-CSF, isotretinoin in combination with irinotecan, and temozolomide (chemo-immunotherapy) can be given safely to patients with high-risk

  • 0 views
  • 29 Jul, 2021
  • 32 locations