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Found 10 clinical trials
  • 24 views
  • 07 Nov, 2020
  • 1 location
High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

therapy followed by peripheral blood stem cell rescue, radiotherapy to the site of the primary tumour and immunotherapy (R4 randomization - isotretinoin and ch14.18/CHO (Dinutuximab beta, Qarziba

filgrastim
colony stimulating factor
monoclonal antibody ch14.18
etoposide
granulocyte colony stimulating factor
  • 310 views
  • 26 Jan, 2021
  • 126 locations
A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or ALK Inhibitor Therapy Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL)

This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Lorlatinib may stop the growth of tumor cells by blocking …

tumor cells
etoposide
bone marrow procedure
vincristine
high-risk neuroblastoma
  • 117 views
  • 15 Oct, 2022
  • 105 locations
Doxycycline vs Isotretinoin for Acneiform Eruptions of TKI

. Moderate and severe reactions requiring systemic therapy, usually tetracycline antibiotics or isotretinoin. No randomized trial has compared the relative effectiveness of tetracyclines versus isotretinoin

  • 0 views
  • 15 Sep, 2021
  • 1 location
Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Acne Vulgaris

conventional dose of oral isotretinoin for treatment of moderate or severe acne vulgaris. The hypothesis is that the painless ALA- PDT will be equally or more efficacious as oral isotretinoin, and taking

isotretinoin
photodynamic therapy
aminolevulinic acid
  • 38 views
  • 18 Feb, 2022
  • 1 location
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne

requires treatment with systemic medications such as oral antibiotics, hormonal therapies such spironolactone, and isotretinoin. Sebum overproduction is fundamental to the pathogenesis of acne with

Accepts healthy volunteers
  • 0 views
  • 14 Jun, 2022
  • 5 locations
The ASCEND Study: Evaluating TMB-001 in the Treatment of RXLI or ARCI Ichthyosis (ASCEND)

This is a randomized, double-blind and vehicle-controlled Phase III study to evaluate the safety and efficacy of topical TMB-001 0.05% ointment for the treatment of CI in subjects with either the RXLI or ARCI subtypes. In addition, a subset of preselected centers will recruit subjects in parallel with either the …

  • 0 views
  • 04 Oct, 2022
  • 18 locations
High Dose Chemotherapy and Autologous Transplant for Neuroblastoma

This is a standard of care document, outlining the therapy for children with high risk neuroblastoma who are not eligible for Children's Oncology Group (COG) studies.

filgrastim
tretinoin
shortening fraction
stem cell transplantation
high dose chemotherapy
  • 5 views
  • 21 Apr, 2022
  • 1 location
Profiling the Skin Microbiome in Response to Altreno in Acne Patients

The study objective is to characterize the shift in the diversity and abundance of the skin microbial community at baseline and in response to Altreno monotherapy as compared to benzoyl peroxide (BPO) 2.5% leave-on gel monotherapy in acne patients.

  • 59 views
  • 04 Oct, 2022
The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans

There are currently no effective treatments for lichen planus pigmentosus (LPP) and erythema dyschromicum perstans (EDP). Tranexamic acid, which may downregulate pigmentation through a reduction in plasmin, has been shown to decrease pigmentation in patients with melasma, another pigmentary disorder. Given that LPP, EDP, and melasma are all disorders of …

  • 101 views
  • 13 Mar, 2022
  • 1 location