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Found 39 clinical trials
Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx MDR-TB)

The purpose of this study is to compare the efficacy and safety of 26 weeks of delamanid (DLM) versus 26 weeks of isoniazid (INH) for preventing confirmed or probable active tuberculosis (TB

isoniazid
atazanavir
platelet count
hysterectomy
chest radiograph
  • 325 views
  • 16 May, 2022
  • 25 locations
Treatment of Latent Tuberculosis in Socially Marginalised Citizens

isoniazid for 6 months or weekly rifapentine and isoniazid as directly observed therapy for twelve weeks.

  • 0 views
  • 05 Aug, 2021
  • 2 locations
Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB (DRAMATIC)

Multidrug-resistant tuberculosis (MDR-TB) is tuberculosis (TB) that is resistant to at least isoniazid and rifampicin, the two most important anti-TB drugs. It occurs in 3.6% of newly diagnosed

  • 0 views
  • 15 Jun, 2022
  • 1 location
Azithromycin as Host-directed Therapy for Pulmonary Tuberculosis

effects in other lung diseases. Objective To investigate the immunomodulatory effects of azithromycin in tuberculosis patients receiving standard therapy (isoniazid

  • 0 views
  • 19 Apr, 2022
  • 1 location
The Individualized M(X) Drug-resistant TB Treatment Strategy Study

This is a randomized controlled clinical trial comparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis guidelines.

extensively drug-resistant tuberculosis
pulmonary tuberculosis
treatment regimen
rifampin
antiretroviral
  • 25 views
  • 15 Feb, 2021
  • 1 location
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36~44 weeks) in subjects with multidrug-resistant tuberculosis (MDR-TB) compared to WHO …

pulmonary tuberculosis
rifampin
pyrazinamide
linezolid
smear
  • 0 views
  • 24 Jan, 2021
  • 13 locations
Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide

Tuberculosis (TB) treatment is long and complex with the risk of poor treatment adherence and treatment failure. Several attempts to shorten treatment of drug-susceptible TB have been unsuccessful. However, recent data support a shortened regimen for mild and moderate pulmonary TB and simultaneous optimization of rifampicin (RIF) and pyrazinamide (PZA). …

  • 0 views
  • 31 Aug, 2021
  • 1 location
Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial)

The Options for Delivering Isoniazid-Rifapentine (3HP) for TB Prevention (3HP Options Implementation Trial) study will be a three-arm, open-label, parallel, randomized trial. This hybrid

isoniazid
HIV Infection
rifapentine
  • 0 views
  • 03 Sep, 2021
  • 1 location
Determination of Adequate Tuberculosis Regimen in Patients Hospitalized With HIV-associated Severe Immune Suppression (DATURA)

treatment in HIV-infected adults and adolescents hospitalized for TB with CD4 ≤ 100 cells/μL over 48 weeks: Intensified TB treatment regimen: increased doses of rifampicin and isoniazid

  • 0 views
  • 11 May, 2022
Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals

This study will evaluate the potential drug-drug interactions between dolutegravir (DTG) and steady state rifapentine (RPT) when RPT is given with isoniazid (INH) daily for 4 weeks (1HP) as part

isoniazid
urine test
skin test
platelet count
hysterectomy
  • 20 views
  • 02 May, 2022
  • 10 locations