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Found 9 clinical trials
Administration of Adipose-derived Stem Cells (ASC) in Patient With Critical Limb Ischemia

Different types of stem cells have recently been studied in clinical trial on ischemic disease of the heart and muscular arteries. Adipose derived stem cell, have shown in vitro and in vivo models a stronger potential of success in recovering from ischemic disease and oxygenation of the tissues. The investigators …

  • 25 Jan, 2021
  • 2 locations
The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM

This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 5. Minimisation will be used to assign eligible subjects in a 2:1 ratio to receive a single intra-arterial administration of REX-001 or matching placebo into the index limb.

hemoglobin a1c
ischemic ulcer
glycosylated hemoglobin
  • 29 Jan, 2022
  • 14 locations
Evaluation of the Impact of the Repositioning Schedule Adapted to the Risk of Pressure Ulcer of Patients in Intensive Care Unit

Pressure ulcers represent a major health issue because of their high incidence and their important consequences. There is an important risk of pressure ulcer acquisition for ICU patients with acute organ failure(s). Specific risk factors identified in ICU are immobility, which accentuates the effects of friction and shears, as well …

  • 13 Aug, 2021
  • 1 location
Swedish Drug-elution Trial in Peripheral Arterial Disease

ischemic ulcers/gangrene (critical limb ischemia), putting the extremity at risk of amputation, to exercise-induced pain (intermittent claudication), limiting the patients daily activities. Invasive

limb ischemia
coronary artery disease
vascular disease
endovascular procedure
  • 26 Jan, 2021
  • 1 location
Study of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects With Peripheral Ischemic Ulcers

This study will assess the safety and efficacy of intramuscular injection of AMG0001 (hepatocyte growth factor [HGF] plasmid) to improve ulcer healing and perfusion in patients with peripheral artery disease.

ischemic ulcer
glycosylated hemoglobin
  • 26 Feb, 2022
  • 19 locations
Post-operative Complication Impulsive Compression in Situ Bypass

To investigate whether compression therapy with foot pump reduce post-operative edema, facilitate wound healing of operation wounds, promote healing of ischemic ulcers and shorten

  • 26 Jan, 2021
  • 1 location
Treatment of No-option CLI by G-CSF-mobilized PB-MNC

pain, non-healing ischemic ulcer or gangrene will be randomized into 2 groups. The control group will be treated by medication and supportive treatment. The experiment group will be injected G-CSF

ischemic ulcer
granulocyte colony stimulating factor
rest pain
  • 14 Feb, 2022
  • 1 location
MAtrix Therapy for Hard-to-heal ChrOnic Wounds (MATHCOW)

CACIPLIQ20® is currently a class III CE marked medical device available in various European and non-European countries, and currently primarily used in managing hard-to-heal wounds. This study is a prospective and standardized recording of patients' data followed in real-life conditions to appreciate the benefits of a therapeutic strategy including CACIPLIQ20® …

  • 07 Mar, 2022
  • 1 location
Autologous Fat Grafting in the Treatment of Critical Limb Ischaemia

Critical Limb Ischaemia (CLI) is a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene for more than 2 weeks in one or both legs, attributable to objectively proven arterial occlusive disease.CLI is associated with a high risk of lower amputation, diminished quality of life and mortality. Revascularization by …

  • 19 Feb, 2021
  • 1 location