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Found 1123 clinical trials
Featured trial
Sternal Cerclage (sternal bone closure after open heart surgery)

The purpose of the study is to learn which treatment option is better for patients who have multi-vessel coronary artery disease (blockages in more than one vessel supplying blood to the heart muscle).

coronary revascularization
revascularisation
acute coronary syndrome
  • 1647 views
  • 05 Feb, 2021
  • 1 location
Featured trial
A Phase Ii, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Ro4602522 Added To The Background Therapy Of The Acetylcholinesterase Inhibitors Donepezil Or Rivastigmine In Patients With Moderate Severity Alzheimer's Disease

A Phase Ii, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Ro4602522 Added To The Background Therapy Of The Acetylcholinesterase Inhibitors Donepezil Or Rivastigmine In Patients With Moderate Severity Alzheimer's Disease

  • 174 views
  • 25 Mar, 2021
  • 1 location
Field Randomization of Nerinetide (NA-1) Therapy in Early Responders (FRONTIER)

The purpose of this study is to determine whether nerinetide (NA-1) is effective in reducing global disability in patients with acute cerebral ischemia if administered early after symptom onset

  • 29 views
  • 11 Jul, 2022
  • 4 locations
Outcome in Patients Treated With Intraarterial Thrombectomy - optiMAL Blood Pressure Control (OPTIMAL-BP)

guideline is adopted even though the possibility of intracerebral hemorrhage or reperfusion injury by high blood pressure. On the other hand, too low blood pressure can worsen cerebral ischemia.

hypertension
cerebral infarction
arterial occlusion
thrombectomy
stroke
  • 0 views
  • 22 Aug, 2021
  • 1 location
Study on Early Brain Injury Mechanism and Comprehensive Intervention of VCI

. After nearly 20 years of experimental research and preliminary clinical observation, it is proposed that chronic cerebral ischemia can not only be a clinical disease entity, but also an important

  • 26 views
  • 19 Aug, 2021
  • 1 location
Delirium Reduction by Volatile Anesthesia in Cardiac Surgery (DELICATE)

Parallel group, prospective, randomized, controlled, single-blinded trial. The aim of our study is to test the hypothesis that volatile anesthesia would reduce the incidence of early postoperative delirium in patients undergoing cardiac surgery with CPB as compared to TIVA.

propofol
anesthesia
heart surgery
postoperative delirium
  • 18 views
  • 07 Oct, 2022
  • 4 locations
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease (ACHIEVE)

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

  • 214 views
  • 18 Oct, 2022
  • 60 locations
Imatinib in Acute Ischaemic Stroke

A clinical trial comparing treatment with Imatinib to placebo when administered within 8 hours of stroke onset for 6 days, in addition to conventional stroke treatment after acute ischaemic stroke.

  • 28 views
  • 15 Feb, 2022
  • 13 locations
WithHolding Enteral Feeds Around Blood Transfusion (International) (WHEAT)

The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize …

  • 0 views
  • 16 May, 2022
  • 1 location
Italian Digital Primary Cardiovascular Prevention Study (CV-PREVITAL)

The CV-PREVITAL study is a randomised clinical trial (RCT) controlled versus usual-care designed to compare the effectiveness of a mobile health (mHealth) intervention with that of usual care in reducing specific cardiovascular (CV) risk factors (in the short term) and the occurrence of vascular events (in the long term). Promoted …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 29 locations