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Found 18 clinical trials
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C1071003 MagnetisMM-3  

The purpose of the study is to evaluate whether single-agent PF-06863135 can provide clinical benefit in participants with relapsed/refractory multiple myeloma. PF-06863135 is a bispecific antibody: binding of PF-06863135 to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity.

refractory multiple myeloma
  • 0 views
  • 30 Jul, 2021
  • 3 locations
Isatuximab in Combination With Novel Agents in RRMM - Master Protocol

Primary Objectives: Part 1 (dose finding, experimental substudies): To determine or confirm the recommended dose of novel agents when combined with isatuximab with or

  • 0 views
  • 14 Jun, 2021
  • 9 locations
Safety Pharmacokinetics and Efficacy of Subcutaneous Isatuximab in Adults With Warm Autoimmune Hemolytic Anemia

Primary Objective: -Part A: To evaluate the safety and tolerability of subcutaneous injections of isatuximab in adults with wAIHA Part B: To evaluate the efficacy of the selected dose in

  • 0 views
  • 16 Jun, 2021
  • 2 locations
Multi-center Open-label Phase 1b Study in Patients With Relapsed/Refractory Multiple Myeloma (RRMM)

Primary Objectives: To evaluate the safety and tolerability of isatuximab administered subcutaneously (SC) versus intravenously (IV) To assess the safety and tolerability

dexamethasone
lenalidomide
measurable disease
refractory multiple myeloma
pomalidomide
  • 32 views
  • 11 Jun, 2021
  • 16 locations
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

Primary Objectives: Safety run-in: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering

dexamethasone
lenalidomide
bone marrow procedure
smoldering myeloma
bone marrow plasma cells
  • 12 views
  • 20 Jun, 2021
  • 62 locations
Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia

Primary Objective: To evaluate the anti-leukemic activity of isatuximab in combination with standard chemotherapies in pediatric participants of ages 28 days to less than 18 years with

idarubicin
residual tumor
fludarabine
myeloid leukemia
salvage therapy
  • 14 views
  • 14 Jun, 2021
  • 71 locations
Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL)

This protocol is a phase III study designed to compare the efficacy and the safety of Isa-KRd induction, transplant, Isa-KRd post ASCT consolidation and Isa-KRd light consolidation vs KRd induction, transplant, KRd post ASCT consolidation and KRd light consolidation After confirmation of eligibility criteria patients will be randomized to one …

  • 0 views
  • 27 Jan, 2021
  • 7 locations
Isatuximab Lenalidomide Bortezomib and Dexamethasone in NDMM

This research is testing whether the investigational drug isatuximab is safe and effective when used in combination with standard agents for the treatment of newly diagnosed multiple myeloma.

dexamethasone
lenalidomide
measurable disease
platelet count
bortezomib
  • 0 views
  • 01 Aug, 2021
  • 1 location
Isatuximab Bendamustine and Prednisone in Refractory Multiple Myeloma

Isatuximab targets and kills CD38-positive myeloma cells in manner similar to rituximab's mechanism of action on CD20-positive lymphoma cells. Based on the synergy between rituximab and

monoclonal protein
prednisone
proteasome inhibitor
bone marrow plasma cells
plasmacytoma
  • 0 views
  • 12 Apr, 2021
  • 1 location
Rapid-infusion Isatuximab in Relapsed/Refractory Multiple Myeloma

This phase II trial studies the effects of isatuximab given as a rapid-infusion in treating multiple myeloma that has come back (recurrent) or has not responded to treatment (refractory

  • 0 views
  • 07 Jun, 2021
  • 1 location