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Found 31 clinical trials
Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

Background Bone marrow failure diseases are rare. Much is known about the diseases at the time of diagnosis, but long-term data about the effects of the diseases and treatments are lacking. Researchers want to better understand long-term outcomes in people with these diseases. Objective To follow people diagnosed with acquired …

  • 0 views
  • 21 Jul, 2022
  • 1 location
Monitoring of Anti-SARS-CoV-2 (COVID 19) and Encapsulated Vaccination Patients With Thalassemic and Falcemic Syndromes (HEMOGLOB-VAX)

There is an urgent need to rapidly evaluate anti-Covid 19 vaccination treatments, in terms of immune response (humoral and cell-mediated) together with the verification of the effectiveness of the vaccine in preventing SARS-CoV-2 infection in thalassemic subjects. It is also necessary to increase scientific knowledge in order to improve clinical …

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 9 locations
MRI QSM Imaging for Iron Overload

, investigators will determine the accuracy, repeatability, and reproducibility of abdominal QSM for iron quantification in patients with liver iron overload. Excessive accumulation of iron in various

MRI
  • 0 views
  • 26 Mar, 2022
  • 1 location
Decompensation of Cirrhosis and Iron Metabolism

Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels. In line with the major role of

gastric varices
acute on chronic liver failure
encephalopathy
hypertension
ascites
  • 0 views
  • 27 Jul, 2021
  • 1 location
T1rho Imaging of Liver in Presence of Iron

Liver T1rho is elevated in response to accumulation of extracellular matrix proteins during fibrosis. The presence of hepatic iron overload; however, can shorten the T1rho value. With proper

Accepts healthy volunteers
fibrosis
iron
  • 0 views
  • 05 Jun, 2022
  • 1 location
Repeatability and Reproducibility of Multiparametric MRI

This study aims to prospectively assess the repeatability and reproducibility of iron-corrected T1 (cT1), T2*, and hepatic proton density fat fraction (PDFF) quantification with multiparametric MRI using the LiverMultiScan (LMS, Perspectum Diagnostics, Oxford, UK) protocol across different field strengths, scanner manufacturers and models.

multiparametric mri
Accepts healthy volunteers
iron
  • 24 views
  • 28 Feb, 2022
  • 1 location
Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis

Patients in maintenance treatment for HFE hemochromatosis since at least one year will be included in a two year study period and randomized in two groups experimental and control group. Because proton pump inhibitors are widely used as chronic medication, and because they can significantly modify iron absorption, patients will …

  • 11 views
  • 26 Jul, 2021
  • 11 locations
Evaluation of Patients With Liver Disease

The proposed study aims to evaluate, investigate, and follow-up patients suffering from acute and chronic liver disease. The study will focus on understanding diseases affecting the liver. Patients participating in the study will first undergo a routine check-up as an outpatient. They will be asked to provide blood and urine …

liver disease
Accepts healthy volunteers
  • 202 views
  • 29 Jul, 2022
  • 1 location
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused Recipients (RBC-IMPACT)

Red Blood Cell - IMProving trAnsfusions for Chronically Transfused recipients (RBC-IMPACT) is an observational cohort study to assess donor, component, and recipient factors that contribute to RBC efficacy in chronically and episodically transfused patients. The objective of the study is to determine how specific genetic and non-genetic factors in donors …

anemia
thalassemia
  • 0 views
  • 06 Apr, 2022
  • 1 location
Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia (CVR)

This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects. The key purpose is to understand how brain blood flow reserve (the ability of the brain to increase its flow in response to stress) is altered in patients with chronic …

transfusion dependent thalassemia
anemia
Accepts healthy volunteers
acetazolamide
hydroxyurea
  • 18 views
  • 27 Jul, 2022
  • 1 location