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Found 29 clinical trials
Featured trial
An observational, multi-center study to evaluate the safety of deferasirox in the treatment of pediatric patients with non-transfusion-dependent iron overload.

An observational, multi-center study to evaluate the safety of deferasirox in the treatment of pediatric patients with non-transfusion-dependent iron overload.

  • 331 views
  • 25 Mar, 2021
  • 1 location
Featured trial
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - Australia  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

epoetin alfa
cancer
vasectomy
erythropoietin
  • 16800 views
  • 22 Aug, 2022
  • 7 locations
Featured trial
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - US  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.   This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …

epoetin alfa
cancer
vasectomy
erythropoietin
  • 54541 views
  • 22 Aug, 2022
  • 9 locations
Featured trial
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 – Canada  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.   This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …

epoetin alfa
  • 23120 views
  • 22 Aug, 2022
  • 10 locations
Studies of Phlebotomy Therapy in Hereditary Hemochromatosis

sample collection (about 2 tablespoons) every 1 to 2 weeks after iron stores have been depleted Phlebotomy every 8 to 12 weeks after iron stores are used up to prevent re-build up of excess

Accepts healthy volunteers
  • 114 views
  • 20 Sep, 2022
  • 1 location
Phase 1, Open-Label, Dose Escalation Study to Assess the Safety of Sp-420 in the Treatment of Transfusional Iron Overload in Patients With MDS(Myelodysplastic Syndrome), and MF (Myelofibrosis)

This study enrolls patients with myelodysplastic syndrome (MDS) and myelofibrosis (MFS), with transfusional iron overload and treats them with the investigational iron chelator, SP-420. SP-420

chelators
hysterectomy
packed red blood cells
chelation therapy
oophorectomy
  • 0 views
  • 20 Sep, 2022
  • 1 location
Comparison of Lower-risk MDS Patients With and Without Improvements in Fatigue Following Blood Transfusion Therapy (FITME)

At present, it is unclear why some myelodysplastic patients (MDS) receiving blood transfusion therapy exhibit an increase in Hemoglobin (Hb) without a concurrent improvement in fatigue. Research is thus required to elucidate on why fatigue persists in some MDS patients in order to devise strategies to alleviate fatigue in "non-responders" …

  • 0 views
  • 22 Mar, 2022
  • 1 location
MRI T2* Mapping of Myocardium Liver Pancreas and Pituitary Gland

All patients were investigated using a 3T MRI and 1,5 T MRI scanners. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2

  • 6 views
  • 15 Apr, 2021
  • 1 location
Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded Patients

The safety and efficacy of CN128 is studied in thalassaemia with sever liver iron overloaded patients.

chelators
blood transfusion
thalassemia
serum ferritin level
iron chelator
  • 0 views
  • 12 Aug, 2022
  • 1 location
Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients (FeVitC)

evaluate the effects of intravenous ascorbic acid administration in hemodialysed patients with iron overload.

  • 0 views
  • 28 Feb, 2022
  • 1 location