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Found 204 clinical trials
Multimodal MRI for MRgFUS Central Lateral Thalamotomy in Neuropathic Pain

To explore the pathogenesis underlying neuropathic pain as well as the mechanisms of pain relief after Magnetic resonance-guided focused ultrasound (MRgFUS) Central Lateral Thalamotomy through multi-model MRI study, and to identify imaging biomarkers for triaging patients and predicting the clinical outcomes. Craniofacial neuropathic pain is one of the most serious …

pain relief
  • 0 views
  • 24 Nov, 2021
  • 1 location
Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome

Postural Tachycardia Syndrome (POTS) is the most common autonomic disorder and is estimated to affect 3,000,000 individuals in the United States, with 80-85% of patients being women. The condition is characterized by a rapid increase in heart rate (HR) that occurs on standing, and chronic symptoms of cerebral hypoperfusion leading …

  • 0 views
  • 16 May, 2022
  • 1 location
Plasma Hydrogen Sulfide as a Biomarker for Alzheimer's Disease and Related Dementias

Hydrogen sulfide is a signaling molecule that is important for vascular health. Because vascular factors such as hypertension and high cholesterol are risk factors for Alzheimer's disease and related dementias, we hypothesize that hydrogen sulfide plays an important role in brain health as well. We will compare blood levels of …

dementia
Accepts healthy volunteers
cognitive decline
depression
alzheimer's disease
  • 0 views
  • 25 Jan, 2022
  • 1 location
Visualization of Neural Targets With 3T MRI

Functional neurosurgery is dedicated to modulating aberrant neural circuits associated with a wide range of neurological conditions. Recently, technological advances in MRI have permitted marked improvements in the direct visualization of neural targets, which is necessary for the accurate targeting in functional neurosurgery procedures. This research study focuses on imaging …

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis (INsIDER)

This project is to: Quantify differences in axonal integrity and organization in aMS versus naPMS patients. Quantify changes in axonal integrity and organization in aMS versus naPMS patients over a two-year period. Validate the combination of imaging parameters that best differentiate aMS versus naPMS patients using histopathology.

disease or disorder
MRI
Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
Multimodal Imaging of MS Reveals the Smoldering Inflammation (PLAQ-MS)

To evaluate active MS plaque evolution with conventional MRI, QSM-post processing, TSPO-PET imaging and P2X7-PET imaging.

disease or disorder
Accepts healthy volunteers
  • 10 views
  • 24 Feb, 2022
  • 1 location
Efficacy and Safety of Luspatercept: A Study by Fondazione Italiana Sindromi Mielodisplastiche (FISiM-Luspa)

Myelodysplastic syndromes (MDS) are a group of malignancies characterized by reduced differentiation and increased apoptosis of hematopoietic progenitor cells, leading to ineffective hematopoiesis. Treatment of MDS varies according to prognosis. Patients with low IPSS-R risk have a low probability of progression to acute myeloid leukemia (AML) and the treatment is …

anemia
cytopenia
growth factor
myeloid leukemia
leukemia
  • 0 views
  • 07 Oct, 2022
  • 1 location
Imaging Biomarkers in Parkinson Disease

Background Parkinson s disease (PD) causes slow movement, stiffness, and tremor. It results from the loss of a brain chemical called dopamine. PD gets worse over time, but researchers do not fully understand why the brain cells that produce dopamine stop working or die in people with PD. This study …

Accepts healthy volunteers
dopamine
cognitive decline
tremor
  • 117 views
  • 22 Oct, 2022
  • 1 location
Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.

Immune-checkpoint inhibitors have recently become available as a new therapy for a variety of cancers. This drugs function by boosting the anti-cancer immune response, but unfortunately, may cause off-target, non-specific immune activation, resulting in liver and gut toxicity. In order to understand the development of liver immune-related adverse events we …

cancer
lung carcinoma
advanced lung cancer
cancer chemotherapy
  • 0 views
  • 22 Mar, 2022
  • 3 locations
Early Detection of Long-term Diabetic Complications in Children and Adolescents With Type 1 Diabetes

Aims: To investigate early markers of arterial stiffness and nerve dysfunction and the association to an extended glucose metabolic profile comprising glucose control (current and past), glucose variability and insulin sensitivity in children and adolescents with type 1 diabetes (T1D). Background: Most Danish children and adolescents with T1D do not …

insulin
diabetic complications
diabetes
nephropathy
  • 0 views
  • 26 May, 2022
  • 1 location