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Found 33 clinical trials
Featured trial
An observational, multi-center study to evaluate the safety of deferasirox in the treatment of pediatric patients with non-transfusion-dependent iron overload.

An observational, multi-center study to evaluate the safety of deferasirox in the treatment of pediatric patients with non-transfusion-dependent iron overload.

  • 331 views
  • 25 Mar, 2021
  • 1 location
Featured trial
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - Australia  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

epoetin alfa
vasectomy
cancer
erythropoietin
  • 16799 views
  • 01 Jul, 2022
  • 7 locations
Featured trial
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 – Canada  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.   This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …

epoetin alfa
  • 23119 views
  • 01 Jul, 2022
  • 10 locations
Featured trial
COMMANDS - Myelodysplastic Syndromes (MDS) - ACE536-MDS-002 - US  

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.   This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept …

epoetin alfa
vasectomy
cancer
erythropoietin
  • 54371 views
  • 01 Jul, 2022
  • 9 locations
Treatment of Hemochromatosis

sample collection (about 2 tablespoons) every 1 to 2 weeks after iron stores have been depleted Phlebotomy every 8 to 12 weeks after iron stores are used up to prevent re-build up of excess

Accepts healthy volunteers
  • 114 views
  • 02 Jul, 2022
  • 1 location
Safety of SP-420 in the Treatment of Transfusional Iron Overload

This study enrolls patients with myelodysplastic syndrome (MDS) and myelofibrosis (MFS), with transfusional iron overload and treats them with the investigational iron chelator, SP-420. SP-420

chelators
packed red blood cells
iron chelator
serum ferritin level
hysterectomy
  • 0 views
  • 03 Jul, 2021
  • 1 location
The Safety and Efficacy of Deferoxamine for Treating Unresectable Hepatocellular Carcinoma

To investigate the safety and efficacy of deferoxamine (DFO) combined with conventional transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC).

  • 0 views
  • 22 Jan, 2021
Comparison of Lower-risk MDS Patients With and Without Improvements in Fatigue Following Blood Transfusion Therapy (FITME)

At present, it is unclear why some myelodysplastic patients (MDS) receiving blood transfusion therapy exhibit an increase in Hemoglobin (Hb) without a concurrent improvement in fatigue. Research is thus required to elucidate on why fatigue persists in some MDS patients in order to devise strategies to alleviate fatigue in "non-responders" …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

Background Diamond-Blackfan anemia (DBA) is treated with steroids. But some people cannot take steroids, or steroids don t work. Other patients must get blood transfusions regularly which are time consuming and can have significant side effects. The drug eltrombopag can increase red blood cells. Researchers want to see if it …

cell counts
  • 2 views
  • 03 Jul, 2022
  • 1 location
MRI T2* Mapping of Myocardium Liver Pancreas and Pituitary Gland

All patients were investigated using a 3T MRI and 1,5 T MRI scanners. For myocardium, pancreas and pituitary gland iron overload quantification in children we have used special sequences for T2

  • 0 views
  • 15 Apr, 2021
  • 1 location