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Found 5 clinical trials
CD4^LVFOXP3 in Participants With IPEX

This first-in-human, Phase 1 clinical trial will test the feasibility of the manufacturing and the safety of the administration of CD4^LVFOXP3 in up to 36 evaluable human participants with IPEX

  • 0 views
  • 29 Jun, 2022
  • 1 location
Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

stem cell transplantation
hsct
immunosuppression
thiotepa
treatment regimen
  • 125 views
  • 11 May, 2022
  • 1 location
Studies of Disorders With Increased Susceptibility to Fungal Infections

Background Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast. These disorders are often related to problems with the immune system and may have genetic factors, which suggests that researchers should study not only the individual with the disorder, …

immune dysfunction
immune globulin
x-rays
granulomatous disease
myeloperoxidase deficiency
  • 221 views
  • 23 Oct, 2022
  • 1 location
New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies

Primary immune deficiencies (PID) are a group of chronic diseases characterized by recurrent infections. Apart from recurrent infections, in some of PIDs autoimmunity, allergy or malignancy could be accompanied to the diseases. Recently, the advanced sequencing technologies have led to the identification of a growing number of novel PIDs including …

  • 42 views
  • 25 Jan, 2021
  • 1 location
Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations

Background PIDD stands for primary immune dysregulation. It is a general term that includes many different inherited immune system disorders. The immune system is the part of the body that helps fight disease and infection. People with PIDDs can develop many kinds of health problems. One of these is inflammatory …

urine tests
diarrhea
immunodeficiency
enteropathy
immune disorder
  • 13 views
  • 04 Oct, 2022
  • 1 location