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Found 243 clinical trials
Microbiota Intervention to Change the Response of Parkinson's Disease (MICRO-PD)

fluctuations and dyskinesias can become a problem as the condition progresses, causing significant impairment in function and quality of life. The gut microbiome is of increasing interest in PD, potentially

levodopa
dyskinesia
carbidopa
carbidopa/levodopa
  • 35 views
  • 15 Mar, 2022
  • 1 location
Deep Brain Stimulation Surgery for Focal Hand Dystonia

placed in brain areas that affect movement. Stimulating these areas can help block nerve signals that cause abnormal movements. Objectives To test DBS as treatment

focal dystonia
dyskinesia
cramp
botulinum toxin
MRI
  • 43 views
  • 10 May, 2022
  • 1 location
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease

without addressing the underlying mechanisms. Patients with PD who demonstrate significant motor fluctuations and dyskinesia are considered for subthalamic nucleus (STN) deep brain stimulation (DBS

depression
motor symptoms
dyskinesia
tremor
brain stimulation
  • 0 views
  • 25 Jan, 2022
  • 2 locations
Periodic Leg Movements' Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography?

PLMs, particularly dopamine agonists, limit the impact of these abnormal movements on sleep fragmentation, daytime alertness and quality of life. Underdiagnosed PLMs in SCI patients can lead to

spinal cord disorder
spinal cord
multiple sclerosis
  • 0 views
  • 24 Jul, 2021
  • 1 location
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. (PIMPARK)

frequently leads to a worsening of motor signs (parkinsonism or dyskinesias due to the concomitant increase of levodopa doses) and non-motor signs with the appearance of a DA withdrawal syndrome (DAWS).

anticholinergic agents
dyskinesia
dopamine agonists
hallucinations
levodopa
  • 2 views
  • 25 Mar, 2022
  • 3 locations
Metacognitive Therapy and Neuro-physiotherapy as a Treatment for Functional Movement Disorders (ReMAP-FMD)

Patients with functional movement disorders (FMD) present with abnormal movements incompatible with symptoms of well-defined neurological disorders and are not associated with structural

  • 0 views
  • 22 Apr, 2022
Intranasal Dexmedetomidine Versus Oral Midazolam as Premedication for Propofol Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging

, largely due to involuntary movements of the child. Preoperative stress can be emotionally traumatic for the child and may even extend beyond the perioperative period, hence the importance of

  • 0 views
  • 09 Apr, 2022
  • 1 location
Intervention in Chronic Pediatric Patients and Their Families. (FACTORADAPT)

This project consists of a psychological intervention in patients and their families with different chronic diseases in order to carry out a comparative study between medical pathologies to know which are the protective or risk variables for the adaptation to the disease.

chronic diseases
chronic disease
Accepts healthy volunteers
  • 0 views
  • 05 Apr, 2022
Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease

To study the effects of Botulinum toxin type A (BTXA) in the treatment of foot dystonia-associated pain in Parkinson's disease

antiparkinsonian agents
  • 0 views
  • 25 Jan, 2022
  • 1 location
The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy

This is an exploratory pilot study to identify neural correlates of specific motor signs in Parkinson's disease (PD) and dystonia, using a novel totally implanted neural interface that senses brain activity as well as delivering therapeutic stimulation. Parkinson's disease and isolated dystonia patients will be implanted unilaterally or bilaterally with …

dyskinesia
cognitive impairment
botulinum toxin
parkinson's disease
brain stimulation
  • 98 views
  • 10 Feb, 2022
  • 1 location