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Found 243 clinical trials
Preparing for Prevention of Huntington's Disease (PREVENT-HD) (PREVENT-HD)

This is a prospective investigation which aims to address key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD). The project will provide necessary psychometric data for clinical outcome assessments (COAs) and biomarkers (BMs) in the cerebral spinal fluid (CSF) to address questions of …

genetic test
cognitive assessment
Accepts healthy volunteers
  • 27 Apr, 2022
  • 1 location
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease (ChANGE HD)

Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT). This disease has classically been conceptualized as a neurodegenerative disease. However, recent evidence suggests that abnormal brain …

diffusion tensor imaging
cognitive assessment
neurodegenerative diseases
autosomal dominant
htt gene
  • 15 May, 2022
  • 5 locations
Measuring Cortisol Levels in Persons With Parkinson's (PD) (CORT-PD)

The objective of this study is to evaluate the cortisol awakening response with persons with Parkinsons Disease (PD), Huntingtons Disease (HD), and controls. These data are desired so experience can be gained with measuring stress levels subjectively and objectively in persons with PD, HD, and controls.

movement disorder
huntington's disease
Accepts healthy volunteers
nervous system disorder
parkinson's disease
  • 09 May, 2022
  • 2 locations
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 and placebo in participants with HD.

  • 10 May, 2022
  • 1 location
A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)

The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance and functioning in participants with HD.

cognitive assessment
  • 11 May, 2022
  • 6 locations
Nordic Throwing Shoulder Project (NTS - Project)

As a part of the Olympic program and with 150 countries in the international Handball Federation team handball has become a worldwide popular sport. Unfortunately, a large number of different types injuries have been reported among team handball players, and shoulder pain has some of the biggest incidence. In handball …

shoulder injury
range of motion
Accepts healthy volunteers
  • 24 Apr, 2022
  • 2 locations
OCTA in Mild Cognitive Impairment and Alzheimer's Disease

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography angiography (OCTA) to assess the structure and function of the retinal microvasculature in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

mild cognitive impairment
optical coherence tomography
neurodegenerative diseases
cognitive impairment
huntington's disease
  • 25 Jan, 2022
  • 1 location
N-Acetyl-L-Leucine for Ataxia-Telangiectasia (A-T)

This is a multinational, multicenter, open-label, rater-blinded prospective Phase II study which will assess the safety and efficacy of N-Acetyl-L-Leucine (IB1001) for the treatment of Ataxia-Telangiectasia (A-T). There are two phases to this study: the Parent Study, and the Extension Phase. The Parent Study evaluates the safety and efficacy of …

  • 18 Feb, 2022
  • 5 locations
Biological Sample Collection for Research and Biobanking

The New York Stem Cell Foundation (NYSCF) is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells). NYSCF uses these samples to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, …

genetic test
genetic testing
Accepts healthy volunteers
  • 06 May, 2022
  • 1 location
Outcomes Mandate National Integration With Cannabis as Medicine for Prevention and Treatment of COVID-19 (OMNI-Can)

This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.

disease or disorder
medical marijuana
brimonidine tartrate ophthalmic solution
Accepts healthy volunteers
  • 16 Mar, 2022
  • 16 locations