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Found 242 clinical trials
A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD)

The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance and functioning in participants with HD.

cognitive assessment
  • 2 views
  • 11 May, 2022
  • 6 locations
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 and placebo in participants with HD.

  • 0 views
  • 10 May, 2022
  • 1 location
A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine)

The purpose of this research study is to see if tetrabenazine, which is commonly used to treat Huntington's Disease (HD), reduces the problems of impulsivity that are common in patients with HD. Investigators will also see how the medicine affects aspects of thinking and mood.

chorea
tetrabenazine
xenazine
  • 0 views
  • 25 Jan, 2022
  • 1 location
iMagemHTT: FIH Evaluation of Novel Mutant Huntingtin PET Radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626

This is a FIH (first-in-human) adaptive PET (Positron Emission Tomography) imaging study to explore the binding and kinetic properties of two potential mutant huntingtin (mHTT) radioligands; [C]CHDI-00485180-R and [C]CHDI-00485626. The binding characteristics of these radioligands will be evaluated first in young (< 35 years of age) healthy control (HC) participants …

body mass index
Accepts healthy volunteers
  • 0 views
  • 24 Jan, 2022
  • 1 location
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington Disease

This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a Phase I/II, randomized, multicenter, dose escalation, double-blind, imitation surgery, first-in-human (FIH) study.

chorea
htt gene
  • 161 views
  • 17 Feb, 2022
  • 12 locations
Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients

Phase A: Recruit 50 patients with HD, and their caregivers, to complete a neuropsychiatric and quality of life battery of scales at baseline. Have these 50 patients complete a formal psychiatric assessment with a psychiatrist within 2 weeks of this clinical battery, and the results of these 2 types of …

neuropsychiatric symptoms
genetic test
agitation
cognitive assessment
depression
  • 80 views
  • 22 Mar, 2022
  • 1 location
Clinical Study to Monitor Plasma Levels of 24OHC in Subject With HD (Chol-HD)

A 2-year clinical longitudinal study to measure plasma concentrations of 24S-hydroxycholesterol, a brain-derived cholesterol catabolite, in subjects with Huntington disease, from the presymptomatic to the symptomatic stages.

24s-hydroxycholesterol
chorea
  • 87 views
  • 26 Feb, 2022
  • 1 location
Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease

The purpose of this study is to assess efficacy and safety of dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg) in patients with irritability due to Huntington's disease.

chorea
Accepts healthy volunteers
dextromethorphan
change of medication
  • 47 views
  • 16 Mar, 2022
  • 1 location
Neurobiological Predictors of Huntington's Disease (PREDICT-HD) (PREDICT-HD)

The purpose of this trial is to study early brain and behavioral changes in people who have the gene expansion for Huntington's disease, but are currently healthy and have no symptoms.

chorea
behavioral problems
  • 1 views
  • 11 Feb, 2022
  • 1 location
Symptomatic Therapy for Patients With Huntington's Disease

Based on the previous symptomatic treatment of Chinese HD patients, this study intends to further optimize the treatment regimen of Chinese HD patients so as to further improve the prognosis of patients.

treatment regimen
risperidone
  • 0 views
  • 24 Jan, 2022
  • 1 location