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Found 243 clinical trials
Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study

The purpose of the study is to evaluate the efficacy of exogenous melatonin in improving sleep quality in HD gene carriers.

change of medication
chorea
  • 12 views
  • 07 Jun, 2022
  • 1 location
Preparing for Prevention of Huntington's Disease (PREVENT-HD) (PREVENT-HD)

This is a prospective investigation which aims to address key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD). The project will provide necessary psychometric data for clinical outcome assessments (COAs) and biomarkers (BMs) in the cerebral spinal fluid (CSF) to address questions of …

genetic test
Accepts healthy volunteers
cognitive assessment
  • 8 views
  • 27 Apr, 2022
  • 1 location
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)

The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 and placebo in participants with HD.

  • 0 views
  • 10 May, 2022
  • 1 location
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington Disease

This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a Phase I/II, randomized, multicenter, dose escalation, double-blind, imitation surgery, first-in-human (FIH) study.

htt gene
chorea
  • 161 views
  • 17 Feb, 2022
  • 12 locations
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease (ChANGE HD)

Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT). This disease has classically been conceptualized as a neurodegenerative disease. However, recent evidence suggests that abnormal brain …

neurodegenerative diseases
autosomal dominant
cognitive assessment
chorea
htt gene
  • 159 views
  • 15 May, 2022
  • 5 locations
Assessing Efficacy of Neuropsychiatric Assessment and Treatment Protocols in Huntington's Disease Patients

Phase A: Recruit 50 patients with HD, and their caregivers, to complete a neuropsychiatric and quality of life battery of scales at baseline. Have these 50 patients complete a formal psychiatric assessment with a psychiatrist within 2 weeks of this clinical battery, and the results of these 2 types of …

cognitive assessment
depression
neuropsychiatric symptoms
psychiatric assessment
agitation
  • 80 views
  • 22 Mar, 2022
  • 1 location
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 20,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD …

chorea
Accepts healthy volunteers
  • 1728 views
  • 19 Apr, 2022
  • 199 locations
Is Caffeine an Environmental Modifier in Huntington's Disease? (CrEAM-HD)

The aim of the study is to establish if caffeine consumption is associated with the evolution of the disease in premanifest HD.

caffeine
chorea
  • 208 views
  • 24 Jan, 2022
  • 10 locations
Deep Brain Stimulation Treatment for Chorea in Huntington's Disease

Evaluating therapeutic effects of globus pallidus internus (GPi) deep brain stimulation (DBS) on Huntington's disease (HD) patients with chorea Explore the relationship between brain network conditions and DBS efficacy in HD patients Explore the effect of different programmed parameters on the treatment of patients with DBS

mental state examination
mini-mental state examination
brain stimulation
change of medication
  • 0 views
  • 24 Jan, 2022
  • 1 location
Adapted Physical Activity Effect on Abilities and Quality of Life of Huntington Patients and Relatives During Rehab Stay (HUNT'ACTIV)

Intro Huntington's disease is a neurodegenerative disease that affects the brain, inducing a dysfunction and death of the middle spiny striatal projection neurons and a progressive alteration of cognitive and motor functions, and psycho-behavioral problems. There is currently no curative treatment but we know hat a multidisciplinary care can optimize …

behavioral problems
neurological examination
cognitive assessment
  • 0 views
  • 25 Jan, 2022
  • 1 location