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Found 243 clinical trials
Hong Kong Spinocerebellar Ataxias Registry

Spinocerebellar ataxias (SCA) 1, 2, 3 and 6 are the most common, autosomal dominantly inherited cerebellar degenerations. And in the Chinese population, the most common SCA is SCA3 and the frequency of SCA 3 among SCA patients is 72.5%, followed by SCA 2 that the frequency is 12% among SCA …

spinocerebellar ataxia type 1
ataxia
Accepts healthy volunteers
spinocerebellar degeneration
sca3
  • 47 views
  • 17 Oct, 2021
  • 1 location
The EUROSCA Natural History Study

The key goals of EUROSCA-NHS is to determine and compare the rate of disease progression in SCA1, SCA2, SCA3 and SCA6 including determination of the order and occurrence of non-ataxia symptoms, assessment of activities of daily living (ADL) and quality of life (QoL), and identification of predictors of disease progression …

spinocerebellar ataxia type 1
ataxia
sca2
sca3
genetic testing
  • 66 views
  • 21 Jan, 2021
  • 14 locations
Neuropsychiatry and Cognition in SCA3/MJD

This research investigates how cognitive-affective aspects evolve during the course of SCA3/MJD. Due to COVID-19 pandemics, this study protocol was adapted for online-only consultations. Evaluations happening after March 2020 have been done by videocall with patients, and no neurological evaluation was thus performed on these patients. A scale on Activities …

  • 0 views
  • 03 Feb, 2021
  • 1 location
Identification of Biomarkers in Spinocerebellar Ataxia 3 (SCA3)

The purpose of this study is to examine the differences in cerebral spinal fluid (CSF) and blood of patients with spinocerebellar ataxias and healthy volunteers. The goal of this project is to identify new biomarkers that are useful for characterizing spinocerebellar ataxias and identify targets for treatment or prevention of …

Accepts healthy volunteers
  • 0 views
  • 21 Mar, 2022
  • 1 location
Effect of Training on Brain Volume in Ataxia

The primary aim is to show balance training improves DCD individual's ability to compensate for their activity limitations, but does not impact disease progression. The second aim is to demonstrate aerobic exercise improves balance and gait in DCD persons by affecting brain processes and slowing cerebellar atrophy.

  • 0 views
  • 21 Mar, 2022
  • 1 location
Chinese Medicine WT for Spinocerebellar Ataxia Type 3

Spinocerebellar ataxia type 3 (SCA3) is one of autosomal dominant hereditary ataxias. Standing imbalance, unsteady gait, dysmetria, fatigue, and depression would occur gradually. There are no effective treatment or palliative methods for patients in the present days. However, low-dose growth hormone, or its downstream product, insulin-like growth factor I (IGF-1), …

  • 3 views
  • 01 Nov, 2021
  • 1 location
Natural History of Spinocerebellar Ataxia Type 7 (SCA7)

Background Spinocerebellar ataxia type 7 (SCA7) is disease in which people have problems with coordination, balance, speech and vision. It is caused by a change in the ATXN7 gene. A mutation in this ATXN7 gene causes changes in eye cells, which can lead to vision loss. There is no cure …

spinocerebellar ataxia type 1
urine tests
electroretinogram
skin biopsy
ataxia
  • 14 views
  • 16 Jun, 2022
  • 1 location
A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3

The primary objective of this study is to evaluate the safety and tolerability of multiple ascending doses of BIIB132 administered via intrathecal (IT) injection to participants with spinocerebellar ataxia type 3 (SCA3). The secondary objective of this study is to characterize the multiple-dose pharmacokinetics (PK) of BIIB132 administered via IT …

  • 0 views
  • 28 Jun, 2022
  • 2 locations
Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease (LCR-MH)

Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have been evoked, including an alteration of the signaling pathway of the Brain Derived Neurotrophic Factor (BDNF), a neurotrophic factor involved in the survival of neurons …

Accepts healthy volunteers
chorea
autosomal dominant
htt gene
  • 0 views
  • 04 Mar, 2022
  • 1 location
Clinical Study to Monitor Plasma Levels of 24OHC in Subject With HD (Chol-HD)

A 2-year clinical longitudinal study to measure plasma concentrations of 24S-hydroxycholesterol, a brain-derived cholesterol catabolite, in subjects with Huntington disease, from the presymptomatic to the symptomatic stages.

24s-hydroxycholesterol
chorea
  • 87 views
  • 26 Feb, 2022
  • 1 location