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Found 242 clinical trials
Effects of a Dynamic Upper Limb Orthosis in Patients With Parkinson's Disease

This is a randomized controlled clinical trial aimed at Parkinson's disease patients. Its objective is to evaluate the effects of a dynamic upper limb orthosis to achieve maximum hand functionality, reducing tremor and rigidity

tremor
hoehn and yahr scale
  • 0 views
  • 25 Jan, 2022
  • 1 location
Physiological Brain Atlas Development (Brain Atlas)

The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but …

tremor
parkinson's disease
dystonia
essential tremor
  • 463 views
  • 15 Jun, 2022
  • 1 location
Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM) (NIVILIUM)

Non-Invasive Mechanical Ventilation (NIV) has been increasingly used in the treatment of acute respiratory failure. Notwithstanding failure rates still remains high, ranging from 5% to 60%. The onset of delirium, agitation, pain and dyspnea may contribute to reduce the success rate of non invasive ventilation treatment. The aim of this …

respiratory failure
acute respiratory failure
dyspnea
agitation
assisted ventilation
  • 4 views
  • 09 Apr, 2022
  • 1 location
Cannabidiol (CBD) for the Treatment of Anxiety and Agitation in Alzheimer's Dementia

"McLean Hospital is recruiting participants with mild to moderate Alzheimer's disease (AD) for an 8-week trial of a custom-made, hemp-derived, high cannabidiol (CBD) sublingual solution for the treatment of anxiety and agitation in AD.  Hemp-derived products may have an anxiolytic effect; thus this study seeks to use a hemp-derived, high CBD …

agitation
alzheimer's disease
  • 0 views
  • 03 Mar, 2022
  • 1 location
Cannabidiol Solution for the Treatment of Behavioral Symptoms in Older Adults With Alzheimer's Dementia (CBD)

This is an open label, eight week, clinical trial of a proprietary high CBD/low THC sublingual solution for the treatment of clinically significant anxiety and agitation in mild to moderate Alzheimer's Disease.

alzheimer's disease
agitation
cannabidiol
anxiety
behavioral symptoms
  • 151 views
  • 20 Apr, 2022
  • 1 location
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study

In this study, the investigators hypothesize that studying monogenic variants with strong effect associated with severe insulin deficiency of Wolfram syndrome will provide important insights into the more complex type 1 and type 2 diabetes mellitus. Aim 1. Establish and maintain a registry of patients with Wolfram syndrome. An Internet …

deficit
hard of hearing
ataxia
diabetes mellitus
deficiency
  • 225 views
  • 13 May, 2022
  • 1 location
Natural History of Glycosphingolipid and Glycoprotein Lysosomal Storage Disorders

This study will evaluate children with glycosphingolipid (GSL) storage disorders to investigate brain changes that cause nervous system degeneration. No experimental treatments are offered in this study; participants will receive standard medical care for their disease. The information from this study may help researchers develop new therapies for these disorders …

MRI
deficiency
  • 76 views
  • 17 Jun, 2022
  • 1 location
Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease

This is a Phase 3, open-label study to evaluate the long-term safety and tolerability of valbenazine, and to provide subjects continued access to valbenazine for the treatment of chorea associated with Huntington disease.

valbenazine
  • 0 views
  • 27 Apr, 2022
  • 30 locations
Instrumented Data Exchange for Ataxia Study (IDEA)

This research study is testing body-worn sensors to measure movement during simple tests of coordination, in order to evaluate the progression and severity of ataxia.

Accepts healthy volunteers
genetic testing
  • 93 views
  • 29 May, 2022
  • 4 locations
Hong Kong Spinocerebellar Ataxias Registry

Spinocerebellar ataxias (SCA) 1, 2, 3 and 6 are the most common, autosomal dominantly inherited cerebellar degenerations. And in the Chinese population, the most common SCA is SCA3 and the frequency of SCA 3 among SCA patients is 72.5%, followed by SCA 2 that the frequency is 12% among SCA …

sca3
spinocerebellar degeneration
ataxia
Accepts healthy volunteers
spinocerebellar ataxia type 1
  • 47 views
  • 17 Oct, 2021
  • 1 location