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Found 116 clinical trials
A Phase 1 Study of Intravesical VAX014 for Instillation in Subjects With Non-Muscle Invasive Bladder Cancer

The purpose of this research study is to evaluate the safety, tolerability and activity of VAX014 for Instillation (VAX014) in patients with low-grade Non-Muscle Invasive Bladder Cancer (NMIBC

bladder cancer
tumor cells
cancer
absolute neutrophil count
invasive bladder cancer
  • 14 views
  • 26 Jan, 2021
  • 5 locations
A Study of Pemigatinib in Non-muscle Invasive Bladder Cancer Patients With Recurrent Low- or Intermediate-Risk Tumors

This phase II trial studies how well Pemigatinib (an orally administered inhibitor of fibroblast growth factor receptors 1, 2, and 3) works in non-muscle invasive bladder cancer (NMIBC) patients

cystoscopy
bladder carcinoma
transurethral resection
cancer
transurethral bladder excision
  • 48 views
  • 26 Jan, 2021
  • 1 location
Durvalumab and Vicinium in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG)

Background Non-muscle-invasive bladder cancer is in the early stages. But it usually comes back after treatment. The drugs Vicinium and Durvalumab may help the

durvalumab
cystoscopy
transurethral resection
cancer
carcinoma
  • 255 views
  • 09 Apr, 2021
  • 1 location
Complete Local Response to Neoadjuvant Chemotherapy in Patients With Muscle Invasive Bladder Cancer Evaluated by 15O-H2O PET/MR

Treatment of localized muscle invasive bladder cancer (MIBC) is radical cystectomy. Neoadjuvant chemotherapy (NAC) improves survival. Approximately 50-60% of all MIBC patients undergoing

bladder tumor
bladder cancer
radical cystectomy
EGFR
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Acupuncture for the Treatment of Intravesical BCG-Related Adverse Events in High-Risk Non-muscle Invasive Bladder Cancer

This phase II trial studies the safety and feasibility of utilizing acupuncture in patients with high-risk bladder cancer that has not spread to the surrounding muscle (non-muscle invasive) undergoing treatment with Intravesical BCG. BCG is a weakened form of the bacterium Mycobacterium bovis that does not cause disease. It is …

  • 0 views
  • 18 Feb, 2021
  • 1 location
Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial)

Open-label, interventional, multi-centre, randomized phase II study. Cancer studied is non-metastatic muscle invasive bladder cancer (MIBC). Avelumab administered every 2 weeks is used as

  • 25 views
  • 29 Jan, 2021
  • 13 locations
Surveillance of High-grade Non-muscle Invasive Bladder Tumours Using the Xpert Bladder Cancer Monitor

The study aims to evaluate the potential clinical impact of a highly sensitive urinary marker, the Xpert Bladder Cancer Monitor, regarding possible reduction in number of flexible cystoscopies in an outpatient setting without decreasing recurrence-free survival or increasing risk of progression.

  • 1 views
  • 24 Jan, 2021
  • 3 locations
The Effectiveness and Safety of Neoadjuvant Intravesical Mitomycin-C Instillation

The aim of this study is to evaluate the effectiveness and safety of neoadjuvant intravesical mitomycin-C instillation in non-muscle invasive bladder cancer patients

bladder tumor
bladder cancer
mitomycin
transurethral resection
cancer
  • 12 views
  • 23 Jan, 2021
  • 1 location
Testing the Addition of an Anti-cancer Drug Pembrolizumab to the Usual Intravesical Chemotherapy Treatment (Gemcitabine) for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer

This phase II trial studies the effect of adding pembrolizumab to gemcitabine in treating patients with non-muscle invasive bladder cancer whose cancer does not respond to Bacillus Calmette

  • 60 views
  • 11 Apr, 2021
  • 283 locations
A Study of Mitomycin-c/ Capecitabine ChemoRadiotherapy Combined With Nivolumab Monotherapy or Ipilumimab and Nivolumab as Bladder Sparing Curative Treatment for Muscle Invasive Bladder Cancer: the CRIMI Study

) subjects with non-metastatic muscle invasive bladder cancer that qualify for ChRT with curative intent.

bladder carcinoma
transurethral resection
carcinoma of the bladder
serum pregnancy test
carcinoma
  • 0 views
  • 25 Jan, 2021
  • 2 locations