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Found 116 clinical trials
AGEN1884 Plus AGEN2034 Combined With Cisplatin-Gemcitabine for Muscle-Invasive Bladder Cancer

This is a phase II trial to evaluate the tolerability, efficacy, and immune outcomes of AGEN1884 plus AGEN2034 concurrent with cisplatin and gemcitabine in the neoadjuvant treatment of muscle-invasive, non-metastatic bladder cancer prior to radical cystectomy.

carcinoma
radical cystectomy
metastatic bladder carcinoma
cisplatin/gemcitabine
metastatic urothelial carcinoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
Intravesical Gemcitabine and Docetaxel for BCG na ve Non-muscle Invasive Bladder Cancer

invasive bladder cancer (NMIBC). All participants will receive an induction course of gemcitabine/docetaxel instillations followed by maintenance instillations if initial efficacy is seen. In addition to

cancer
carcinoma
invasive bladder cancer
docetaxel
bladder cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Paclitaxel-binding Albumin and Cisplatin as Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer

This is a phase II study of Paclitaxel-binding albumin, Cisplatin as neoadjuvant chemotherapy in patients with muscle-invasive urothelial carcinoma of the bladder. Patients with muscle invasive urothelial carcinoma who are candidates for radical cystectomy will be enrolled.

  • 0 views
  • 23 Jan, 2021
  • 1 location
Study of HX008 for the Treatment of BCG-Unresponsive Non-muscle Invasive Bladder Cancer

This is a single-arm, multicenter study to evaluate the efficacy and safety of HX008 injection in patients with BCG-unresponsive non-muscle invasive bladder cancer.

  • 0 views
  • 12 Feb, 2021
  • 5 locations
Study of CAbozantinib in Combination With AtezolizumaB for Muscle-Invasive BladdEr Cancer

This is an open-label phase II study assessing the activity of cabozantinib combined with atezolizumab in patients with resectable muscle-invasive urothelial carcinoma who are ineligible for cisplatin-based therapy or decline cisplatin-based therapy. Each cycle equals 21 days. The dose of atezolizumab is 1200 mg IV flat dose every 3 weeks …

cancer
invasive bladder cancer
carcinoma
transitional cell carcinoma
white blood cell count
  • 0 views
  • 22 May, 2021
  • 3 locations
Electromotive Mitomycin-C (EMDA-MMC) in Preventing Recurrences in High-risk Non-muscle-invasive Bladder Cancer

Disease recurrence and progression is a major issue in high risk non-muscle-invasive bladder cancer (NMIBC). The current study compares two adjuvant instillation therapies in the

cancer
carcinoma
invasive bladder cancer
bladder cancer
mitomycin
  • 18 views
  • 11 Apr, 2021
  • 10 locations
Avelumab Plus Bacille Calmette-Guerin (BCG) in Patients With Non-muscle Invasive Bladder Cancer

The purpose of this study is to test the safety of avelumab and Bacille Calmette-Guerin (BCG) and see what effects (good and bad) that this combination treatment has on subjects with recurrent bladder cancer.

cancer
invasive bladder cancer
avelumab
recurrent bladder cancer
bladder tumor
  • 8 views
  • 24 Jan, 2021
  • 1 location
18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy

This research study is studying a positron emission tomography (PET) agent called 18F-fluciclovine to evaluate how well 18F-fluciclovine-PET scans determine the extent of muscle invasive bladder

cancer
carcinoma
invasive bladder cancer
radiopharmaceuticals
ct scan
  • 1 views
  • 17 Mar, 2021
  • 1 location
Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

This phase III trial studies how well chemotherapy and radiation therapy work with or without atezolizumab in treating patients with localized muscle invasive bladder cancer. Radiation therapy

tumor necrosis factor
skin cancer
cystoscopy
monoclonal antibodies
absolute neutrophil count
  • 37 views
  • 17 Jun, 2021
  • 171 locations
Durvalumab and Vicinium in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG)

Background Non-muscle-invasive bladder cancer is in the early stages. But it usually comes back after treatment. The drugs Vicinium and Durvalumab may help the

cancer
carcinoma
invasive bladder cancer
transitional cell carcinoma
neutrophil count
  • 255 views
  • 16 Jun, 2021
  • 1 location