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Found 132 clinical trials
featured
  • 80 views
  • 03 Dec, 2020
  • 1 location
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer

n the present study the neoadjuvant approach with the anti-HER2 trastuzumab and pertuzumab combined with carboplatin and paclitaxel will be used to compare the Event-Free Survival (EFS) in regimens with and without atezolizumab. Following the neoadjuvant part of the study, after surgery all patients will continue to receive trastuzumab and …

paclitaxel
trastuzumab
tubal ligation
sentinel node
sentinel lymph node biopsy
  • 17 views
  • 24 Jan, 2021
  • 51 locations
Axillary Node Dissection Versus no Dissection in Breast Cancer With Positive Sentinel Lymph Node

investigator propose a Non Inferiority Randomized Multicenter Phase III Trial of Axillary Node Dissection Versus no Axillary Node Dissection in Case of Positive Sentinel Lymph Node in Invasive Breast Cancer

hormone therapy
endocrine therapy
tumor cells
metastasis
sentinel node
  • 0 views
  • 24 Jan, 2021
  • 1 location
RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy

The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.

invasive breast cancer
cancer
breast cancer
adjuvant therapy
  • 28 views
  • 28 May, 2021
  • 36 locations
FFNP-PET/MR Imaging of Progesterone Receptor Expression in Invasive Breast Cancer

breast cancer. The hypothesis is that FFNP SUVmax from PET/MRI will correlate well against the semi-quantitative PR immunohistochemistry score.

progesterone receptor
immunohistochemistry
progesterone
  • 0 views
  • 04 Apr, 2021
  • 1 location
Cemiplimab in High Risk or Locally Advanced Hormone Receptor Positive HER2 Negative or Triple-Negative Breast Cancer

This is a single-arm, open-label, phase 2 study that will enroll 36 subjects, who have pathologically proven diagnosis of invasive breast cancer, clinical stage tumor 1-3 (cT1-T3), node 0-3 (cN0

hormone therapy
paclitaxel
carcinoma in situ
endocrine therapy
direct bilirubin
  • 0 views
  • 22 Sep, 2021
Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer

breast cancer or ductal carcinoma in situ (DCIS). Subjects will be randomized to breast conserving surgery (BCS) utilizing either the BCL or wire localization (WL) to guide surgery.

  • 0 views
  • 22 Jun, 2021
  • 14 locations
Study of Neoadjuvant Chemotherapy Plus Trastuzumab and Pertuzumab in HER2-Negative Breast Cancer Patients With Abnormal HER2 Signaling

-negative invasive breast cancer who have abnormal HER2 signaling activity determined by the Celcuity CELx HER2 Signaling Function (HSF) testing.

bone scan
paclitaxel
immunohistochemistry
cyclophosphamide
HER2
  • 8 views
  • 21 Apr, 2021
  • 42 locations
Radiotherapy in Preoperative Setting With CyberKnife for Breast Cancer

The aim of this study is to prospectively evaluate, in patients affected by early breast cancer, safety and feasibility of single fraction radiotherapy with Cyberknife R in preoperative setting, and to identify factors predictive for outcome based on biologic and clinical parameters.

  • 0 views
  • 23 Jan, 2021
  • 1 location