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Found 193 clinical trials
Featured trial
Hospital Airway Resuscitation Trial (HART)

Cardiac arrest occurring in the hospital is a major burden to patients and their families. Different ways to manage the breathing of patients with cardiac arrest in the hospital are currently being used and it is not clear which is best. This study will help us understand if one approach …

  • 07 Oct, 2022
  • 1 location
Randomized Trial of Sedative Choice for Intubation (RSI)

Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency

  • 04 Oct, 2022
  • 1 location
Pragmatic Trial Examining Oxygenation Prior to Intubation (PREOXI)

-ten emergency tracheal intubations is complicated by life-threatening hypoxemia. Administering supplemental oxygen prior to induction and intubation ("preoxygenation") decreases the risk of life

  • 04 Oct, 2022
  • 10 locations
DirEct Versus VIdeo LaryngosCopE Trial (DEVICE)

. Failure to intubate the trachea on the first attempt occurs in more than 10% of all tracheal intubation procedures performed in the emergency department (ED) and intensive care unit (ICU). Improving

  • 08 Jul, 2022
  • 9 locations
High Flow Nasal Cannula With Noninvasive Ventilation

, spine surgery, or open abdominal procedures) to try and decrease the need for intubation with mechanical ventilation.

  • 26 Apr, 2022
  • 1 location
Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia (PreVent2)

Researchers are looking at two different types of breathing tubes to see if one is better than the other at preventing pneumonia. One of the tubes has a design features to prevent leakage of fluids from the mouth and the back of the throat into the lower airways and lungs. …

  • 06 Feb, 2022
  • 1 location
Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation. (PROLISA)

The investigators propose to evaluate premedication with Propofol compared to a control strategy including a placebo with a possible rescue treatment with ketamine to ensure pain control before LISA Procedure . Investigators hypothesize that sedation with Propofol is safe and non-inferior to placebo for the risk of Mechanical Ventilation in …

  • 18 Feb, 2022
  • 16 locations
Pressure Injury Treatment by Intermittent Electrical Stimulation:

Multicentered randomized controlled study with adaptive design to evaluate if Intermittent Electrical Stimulation (IES) decreases progression and facilitates healing of pressure injuries for patients with, sacral / ischial pressure injuries.

  • 10 May, 2022
  • 3 locations
Incidence of Intraoperative Awareness in Indian Patient Population

The profiling of bi-spectral index (BIS) monitored facilitation of general anesthesia (GA), including, anesthesia induction and maintenance of GA depth state, emergence characteristics, and postoperative recovery parameters, is now extensively available. However, majority of the data supporting the use of BIS have emanated from western Caucasian patient population. Though research …

  • 28 May, 2022
  • 4 locations
A Pragmatic Trial to Evaluate the Intermediate-term Effects of Early, Aggressive Versus Escalation Therapy in People With Multiple Sclerosis (TREAT-MS)

FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other …

  • 20 Oct, 2022
  • 41 locations