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Found 10 clinical trials
A Phase 1a/b Dose Finding, Open-label Study to Evaluate Safety and Toxicity of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer (ADVANCED-1)

intravesical BCG or adults who have received at least one dose of intravesical chemotherapy. Dosing will start in subjects with HGTa or CIS (including CIS with concomitant Ta) NMIBC to include a minimum of 1

  • 0 views
  • 14 Sep, 2022
  • 4 locations
Low Energy Shock Wave Therapy and Non-Muscle Invasive Bladder Cancer

studied via histopathological examination and molecular studies of the resected bladder tissues. The patients will receive intravesical chemotherapy or BCG immunotherapy and they will be followed

  • 0 views
  • 27 Jan, 2021
  • 1 location
A Randomized Phase 2 Study of Erdafitinib Versus Investigator Choice of Intravesical Chemotherapy in Subjects Who Received Bacillus Calmette-Guérin (BCG) and Recurred With High Risk Non-Muscle-Invasive Bladder Cancer (NMIBC) and FGFR Mutations or Fusions

The purpose of this study is to evaluate recurrence-free survival (RFS) in participants treated with erdafitinib vs Investigator's Choice, for participants with high-risk non-muscle-invasive bladder cancer (NMIBC) who harbor fibroblast growth factor receptor (FGFR) mutations or fusions, and who recurred after bacillus calmette-guerin (BCG) therapy.

cancer
transitional cell carcinoma
invasive bladder cancer
bcg vaccine
carcinoma
  • 0 views
  • 20 Sep, 2022
  • 143 locations
Optimal Adjuvant Intravesical Therapy for Intermediate Risk Non Muscle Invasive Bladder Cancer: A Randomized Controlled Trial

bladder cancer by comparing two commonly utilized intravesical regimens; intravesical immunotherapy (BCG) and intravesical chemotherapy.

intravesical chemotherapy
bladder tumor
invasive bladder cancer
intravesical bcg
  • 0 views
  • 23 Mar, 2022
  • 1 location
Gemcitabine Versus Water Irrigation in Upper Tract Urothelial Carcinoma

the use of gemcitabine, especially at lower volume centers. Some evidence suggests that intravesical irrigation with sterile water has equivalent efficacy to intravesical chemotherapy in prevention of

  • 0 views
  • 29 Dec, 2021
  • 1 location
Comparison of the Efficacy and Safety of Continuous and Single-Dose Intravesical Epirubicin Instillation

In this study, the local and systemic side effects, tumor recurrens and progression rates of single or continuous epirubicin instillation during the early postoperative period were investigated in low and intermediate risk non-muscle-invasive bladder cancer.

bladder tumor
invasive bladder cancer
transurethral resection
transurethral bladder excision
  • 0 views
  • 26 Jul, 2022
  • 1 location
Adding Mitomycin to Bacillus of Calmette-Guerin (BCG) as Adjuvant Intravesical Therapy for High-risk, Non-Muscle-invasive Bladder Cancer: a Randomised Phase 3 Trial (BCG+MM)

Open label, randomised phase 3 trial of the addition of Mitomycin to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer. The study aim is to compare disease-free survival between treatment arms: BCG alone versus Mitomycin in addition to BCG.

cancer
invasive bladder cancer
transurethral resection
carcinoma
carcinoma in situ
  • 16 views
  • 15 Sep, 2022
  • 14 locations
Relationship Between Lymph Node Dissection and Prognosis in High-risk NMIBC

There is no consensus on the need for lymph node dissection in radical cystectomy (RC) for high-risk non-muscular invasive bladder cancer (NMIBC). Investigators divided participants at high risk of NMIBC without enlarged lymph nodes as indicated by pelvic MRI into two groups 1:1. One group of participants underwent RC combined …

radical cystectomy
invasive bladder cancer
transurethral resection
bladder tumor
neutrophil count
  • 0 views
  • 24 Nov, 2021
  • 1 location
Antimicrobial Prophylaxis in Patients Who Underwent a Transurethral Resection of Bladder (TURB)

Antimicrobial prophylaxis in urological procedures is aimed to reduce the risk of local and systemic postoperative infections such as urinary tract infection or surgical site infection. It should be recommended only when the potential benefit exceeds the anticipated risks and costs. However, a wide variation in the use of periprocedural …

cancer
TURB
antibiotics
urine culture
transurethral resection
  • 9 views
  • 23 Jan, 2021
  • 1 location
RESECT: Improving Quality in TURBT Surgery. (RESECT)

usage of intravesical chemotherapy varies widely between hospitals and thus may result in worse outcomes for some patients. The primary objective of the study is to determine if audit and

cancer recurrence
invasive bladder cancer
transurethral resection
carcinoma
transurethral bladder excision
  • 0 views
  • 24 May, 2022
  • 1 location