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Found 67 clinical trials
Physical Excercise Program in Children With Drug-resistant Epilepsy (PEPDRE)

Pediatric epilepsy has been described as an age related-condition, and it has a strong impact on childhood quality of life. Psychological symptoms and self-esteem impairment are common facts. Although there are some studies studying the benefits of physical exercise in order to improve seizure control in adults with epilepsy, we …

  • 0 views
  • 01 May, 2022
  • 1 location
Using Micro-filaments to Detect "Fast Ripples" and Improve the Identification of the Epileptogenic Zone (NeuroSeizure)

record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone and investigate the neuronal circuits underlying brain dynamics associated with epilepsy

  • 0 views
  • 11 Mar, 2022
  • 1 location
Model-based Electrical Brain Stimulation

Neuropsychiatric disorders are a leading cause of disability worldwide with depressive disorders being one of the most disabling among them. Also, millions of patients do not respond to current medications or psychotherapy, which makes it critical to find an alternative therapy. Applying electrical stimulation at various brain targets has shown …

  • 0 views
  • 05 May, 2022
  • 2 locations
Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy

The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.

  • 1 views
  • 17 Feb, 2022
  • 1 location
Home Operations Utilizing Stimulation

This project will utilize a home-operated stimulator in 1) a healthy young adult population and 2) a healthy older adult population to provide a proof of concept of home-use of transcutaneous vagal nerve stimulation (tVNS). tVNS is believed to modulate cognitive performance.

Accepts healthy volunteers
  • 0 views
  • 11 Mar, 2022
  • 1 location
Non-invasive Vagus Nerve Stimulation (nVNS) in Pediatric Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

This study will be conducted at Children's Healthcare of Atlanta, in Atlanta, Georgia for a total duration of 24 months. The electrical neuromuscular stimulation device used in this study is the VitalStim 400, which has been used in multiple previous clinical studies for modulation of pain and has received FDA …

immune globulin
plasma exchange
igiv
polyneuropathy
  • 0 views
  • 11 Mar, 2022
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy (MIT-E)

This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase. After completion of the randomized, placebo-controlled phase, participants may enter a 48-week, long-term, extension phase during which they will receive open-label …

electroencephalogram (eeg)
leigh's disease
antiepileptic
ketogenic diet
epilepsy
  • 232 views
  • 18 Apr, 2022
  • 18 locations
Tele-epic (Telemedicine for Epilepsy Care) (Tele-epic)

Epilepsy is a chronic condition that requires consistent follow-up aimed at seizure control, surveillance of comorbidities, monitoring of antiepileptic drugs (AED) levels and side effects. Patients may encounter difficulties to be assessed adequately and the disease burden is increased by the need for travelling across the country for medical consultations. …

seizure
antiepileptic
antiepileptics
epilepsy
  • 0 views
  • 21 Mar, 2022
  • 1 location
cTBS Targeting Cerebellum for Drug-refractory Epilepsy

This study aims to observe the efficacy, durability and safety of cerebellar continuous burst stimulation (cTBS) in the treatment of drug-refractory epilepsy, and to provide a new method for

anti-epileptic drug
antiepileptics
electroencephalogram
seizure
  • 0 views
  • 08 Dec, 2021
  • 1 location
Exercise as Adjunctive Treatment for Refractory Epilepsy

The purpose of this research study is to determine whether a 12-week telehealth aerobic exercise intervention is feasible in people with epilepsy. The study team will also gather information on the effect of the intervention on sleep and stress as mediators of seizure frequency, well as effects on epilepsy and …

generalized epilepsy
adjunctive treatment
seizure
  • 0 views
  • 24 Mar, 2022
  • 1 location