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Found 49 clinical trials
Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

Background More than 130 primary tumors of the central nervous system (CNS) have been identified. Most affect less than 1,000 people in the United States each year. Because these tumors are so rare, there are few proven therapies. This study will test whether the immunotherapy drug nivolumab is an effective …

sarcoma
medulloblastoma
corticosteroids
atypical meningioma
experimental drug
  • 120 views
  • 04 Oct, 2022
  • 11 locations
Use of Non-invasive Optical Analysis in Neurosurgery

The present study aims to investigate the potential application of multispectral analysis, hyperspectral imaging, and fluorescence during neuro-oncological procedures, specifically during brain tumour debulking / resection. These optics techniques are entirely non-invasive and consist in camera with a filter to be linked to the standard microsurgical and endoscopic instruments used …

  • 0 views
  • 02 Sep, 2021
  • 1 location
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2)

progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow people with

brigatinib
ependymoma
investigational drug
neurofibromatosis type 2
measurable disease
  • 40 views
  • 30 Jun, 2022
  • 6 locations
Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors (SEL-TH-1601)

In this research study the researchers want to learn more about the effects (both good and bad) the study drug selumetinib has on participants with neurofibromatosis type II (NF2) related tumor. The researchers are asking patients with NF2 related tumors to be in the study, because their hearing has decreased …

filgrastim
dexamethasone
medical therapy
MRI Scan
tumor growth
  • 639 views
  • 28 Apr, 2022
  • 1 location
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study (HiPPI)

This phase II trial studies how well hypofractionated proton or photon radiation therapy works in treating patients with brain tumors. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells. A shorter duration of radiation treatment may avoid some …

tumor cells
pituitary
meningioma
  • 0 views
  • 04 Jun, 2022
  • 1 location
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this phase 1 trial is to determine the maximum tolerated dose (MTD), food effect, safety and tolerability of oral ONC206 in patients with recurrent, primary CNS neoplasms.

cns tumor
medulloblastoma
oligodendroglioma
oligodendroglioma, anaplastic
cancer chemotherapy
  • 10 views
  • 12 Mar, 2022
  • 1 location
9-ING-41 in Pediatric Patients With Refractory Malignancies.

9-ING-41 has anti-cancer clinical activity with no significant toxicity in adult patients. This Phase 1 study will study its efficacy in paediatric patients with advanced malignancies.

cyclophosphamide
cns tumor
cns tumors
topotecan
irinotecan
  • 0 views
  • 14 May, 2022
  • 8 locations
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy …

conventional treatment
gemcitabine
filgrastim
medulloblastoma
combined modality therapy
  • 231 views
  • 19 Apr, 2022
  • 1 location
Phase 2 Study of Tanezumab in Subjects With Moderate to Severe Pain Due to Schwannomatosis

The primary objective of this study is to determine whether the administration of tanezumab, an anti-nerve growth factor (NGF) antibody, improves pain relief in schwannomatosis patients receiving background non-NSAID therapy.

opioid
gabapentin
neuralgia
pain relief
NSAID
  • 12 views
  • 24 Jan, 2021
Identification by Transcriptomic Approach of New Prognostic and Predictive Markers in a Cohort of Atypical Meningiomas (TransMenAtyp)

Determine by a transcriptomic approach new prognostic and predictive markers in atypical meningiomas (WHO grade II). Retrospective observational study, on a cohort of 85 atypical

  • 0 views
  • 13 Mar, 2022
  • 1 location