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Found 49 clinical trials
A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas

This research study is studying radiation therapy as a possible treatment for meningioma or tumor on the lining of the brain. The study drug or intervention involved in this research study is

karnofsky performance status
atypical meningioma
meningioma
proton therapy
malignant meningioma
  • 240 views
  • 23 Feb, 2022
  • 1 location
Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma

tumors or prior radiation therapy, and a recent case study reported significant reduction of an intracranial meningioma after 6 months of PD-L1 blockade. Radiation has been shown to augment immune

neutrophil count
ebrt
intracranial meningioma
recurrent meningioma
medical therapy
  • 108 views
  • 04 Mar, 2022
  • 1 location
Phase II Study of 177Lu-DOTATATE Radionuclide in Adults With Progressive or High-risk Meningioma

or residual high-risk Ga-DOTATATE PET-MRI positive meningioma. Ga-DOTATATE PET-MRI scans will be obtained prior to initiation of Lutathera treatment and 6 months after the initiation of Lutathera

neutrophil count
residual tumor
ebrt
measurable disease
nitrosoureas
  • 40 views
  • 04 Jun, 2022
  • 2 locations
Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOC

The goal of this study is to propose the first direct comparison of Ga-68-DOTATATE PET and Ga-68-DOTATOC PET in patients with meningioma.

somatostatin
dotatoc
dotatate
  • 3 views
  • 19 Apr, 2022
  • 1 location
An Open-Label Phase II Study of Nivolumab in Adult Participants With Recurrent High-Grade Meningioma

This research study is studying targeted immunotherapies as a possible treatment for recurrent meningioma. The names of the study interventions involved in this study are nivolumab and

neutrophil count
ebrt
ct scan
ipilimumab
recurrent meningioma
  • 242 views
  • 25 Mar, 2022
  • 1 location
Stereotactic Radiosurgery and Immunotherapy (Pembrolizumab) for the Treatment of Recurrent Meningioma

This phase II trial studies the effect of stereotactic radiosurgery and pembrolizumab in treating patients with meningioma that has come back (recurrent). Stereotactic radiosurgery is a type of

  • 22 views
  • 09 Nov, 2021
  • 1 location
A Phase 0/II Study of Ribociclib (LEE011) in Preoperative Rb-Positive Recurrent High-Grade Glioma and Meningioma Patients Scheduled for Resection to Evaluate Central Nervous System (CNS) Penetration

In the proposed trial, patients will be administered ribociclib prior to surgical resection of their tumor. Patients will be enrolled in time-intervals sequentially (non-randomized). All patients will be orally-administered 5 doses of LEE011 (900 mg/d) with the final dose occurring at one of 3 intervals before brain tumor resection.

neutrophil count
brain tumor
toremifene
tamoxifen
metastatic cancer
  • 250 views
  • 16 Sep, 2022
  • 1 location
Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy

This phase II trial studies how well lutathera works in treating patients with meningioma that cannot be treated with surgery (inoperable) and is growing, spreading, or getting worse

  • 5 views
  • 24 May, 2022
  • 1 location
Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas (POPLAR-NF2)

This is a parallel-group, two-staged, Phase 2/3, randomized, multi-center study to investigate the efficacy and safety of REC-2282 in patients with progressive NF2 mutated meningiomas.

  • 0 views
  • 04 Oct, 2022
  • 5 locations
Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma

ipilimumab in treating patients with grade II-III meningioma that has come back (recurrent). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system

  • 18 views
  • 12 Jul, 2022
  • 5 locations