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Found 171 clinical trials
Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's)

Multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of abatacept to achieve sustained glucocorticoid-free remission in patients with relapsing non-severe granulomatosis with polyangiitis (Wegener's) (GPA) . Participants will be randomized 1:1 to receive either abatacept 125 mg or placebo administered by subcutaneous injection once a week. Participants will continue …

chest radiograph
norplant
tooth decay
cavities
eosinophilic granulomatosis
  • 197 views
  • 18 May, 2022
  • 20 locations
Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy (CSS)

Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the majority of patients. In that study, cerebellar SS was associated with a higher number of …

MRI
amyloid deposition
  • 0 views
  • 13 Jun, 2022
  • 1 location
Biodistribution Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis Vasculitis or Pulmonary Sarcoidosis

This study evaluates safety, tolerability, biodistribution and performance of the [68Ga]Ga-DOTA-Siglec-9 following a single intravenous administration in patients with active rheumatoid arthritis, vasculitis or pulmonary sarcoidosis as well as radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and tolerability of the tracer in healthy volunteers.

pulmonary sarcoidosis
vasculitis
  • 0 views
  • 19 Jun, 2021
  • 1 location
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer (ASPECT)

Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them …

ct scan
diagnostic procedures
lung cancer
lung carcinoma
cancer
  • 0 views
  • 04 Jun, 2022
  • 1 location
Hydroxychloroquine in ANCA Vasculitis Evaluation

The purpose of this study is to find out whether hydroxychloroquine, in addition to background treatments, reduces disease activity in patients with Anti-Neutrophilic Cytoplasmic Autoantibodies (ANCA) Vasculitis, a group of autoimmune diseases. Hydroxychloroquine and is an established, effective, safe and inexpensive therapy, widely used in other autoimmune diseases such as …

  • 0 views
  • 26 Jan, 2021
  • 3 locations
Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

The goal of this study is to investigate the efficacy of [68Ga]CBP8 to detect collagen deposition in radiation induced tissue injury.

cancer chemotherapy
chemoradiotherapy
pulmonary resection
lung resections
pdac
  • 0 views
  • 26 Mar, 2022
  • 1 location
Single-centre Study Exploring the Utility of Hyperpolarized 129Xe Magnetic Resonance Imaging in Healthy Volunteers and Patients With Lung Disease

This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.

sarcoidosis
dysplasia
fibrosis
lung disease
respiratory infection
  • 551 views
  • 14 Sep, 2022
  • 1 location
Vasculitis Pregnancy Registry (V-PREG)

The purpose of this study is to learn about the experience of women with vasculitis who become pregnant. In particular, the study will consist of several online surveys to assess each woman's vasculitis severity and pregnancy-related experiences, and pregnancy outcomes.

urticarial vasculitis
purpura
cryoglobulinemic vasculitis
arteritis
iga vasculitis
  • 137 views
  • 30 May, 2022
  • 1 location
Role of Genetic Factors in the Pathogenesis of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

sarcoidosis
fibrosis
pulmonary disease
x-rays
asthma
  • 301 views
  • 22 Sep, 2022
  • 1 location
Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis (LoDoNaVasc)

Naltrexone is an FDA approved drug (for alcoholism) that has found widespread use "off-label" to treat pain and improve quality of life at much lower doses than are used for the approved indication. There are a few scientific studies in three conditions (fibromyalgia, Crohn's disease, and multiple sclerosis) that suggest …

livedo reticularis
asthma
immunosuppressive therapy
arteriosclerosis
vasculitis
  • 196 views
  • 25 Mar, 2022
  • 2 locations