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Found 77 clinical trials
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability (EPR)

The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via altering the sensitivity of the muscle afferent receptors.

Accepts healthy volunteers
vascular disease
peripheral arterial diseases
  • 23 Mar, 2022
  • 1 location
Granulocyte-Macrophage Stimulating Factor (GM-CSF) in Peripheral Arterial Disease

Peripheral artery disease (PAD) is a disease in which plaque builds up in the arteries that carry blood to the head, organs, and limbs. PAD usually occurs in the arteries in the legs, but can affect any arteries. Over time, plaque can harden and narrow the arteries which limits the …

  • 28 Oct, 2021
  • 1 location
Iliac Angioplasties: Impact of the Fusion of Images on the Irradiation Rate (AIFITI)

Atherosclerosis can cause the arteries to narrow (stenosis) or clog (occlude), leading to reduced blood flow. Arteriography or angiography is a radiological examination of the arteries which will make it possible to confirm and quantify the severity of the damage to the artery and which, in certain cases, can be …

  • 12 May, 2022
  • 2 locations
Improving Walking in Peripheral Artery Disease

Peripheral artery disease (PAD) is a cardiovascular disease manifesting from systemic atherosclerosis that blocks the leg arteries and results in insufficient blood flow to the lower extremities. Limb ischemia from PAD is the most common disorder treated within the vascular surgical service of the Omaha Veterans Affairs Medical Center. PAD …

  • 11 Nov, 2021
  • 1 location
Sulodexide in the Treatment of Chronic Primary Venous Disease of the Lower Extremities (SuloPrima)

This study compares the efficacy and safety of sulodexide (Vessel) to placebo in patients with chronic venous disease of the lower extremities. The primary hypothesis is that more patients will achieve a decrease in rVCSS score of at least 4 points with sulodexide than with placebo.

  • 05 May, 2022
  • 14 locations
Exercise Therapy for PAD Using Mobile Health

Peripheral artery disease (PAD) is a highly prevalent condition affecting up to 10% of Veterans that leads to loss of walking ability and increased risk of amputation. Veterans have limited access to supervised exercise therapy, a facility-based program proven to improve walking ability in PAD, which is poorly attended due …

  • 15 Dec, 2021
  • 1 location
Integrating Fall Prevention Balance Exercises Into a Program for Older Adults With Peripheral Artery Disease (PAD): A Mixed Methods Feasibility Study

The overarching objective of this study is to improve fall prevention efforts in community-dwelling older adults with peripheral artery disease (PAD) to reduce falls. To accomplish this, the investigators will conduct a feasibility study and pilot the addition of a balance exercise component to existing supervised exercise therapy (SET) programs …

  • 21 Jul, 2022
  • 1 location
Aspirin® Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS (ARIVA)

To show if a combination therapy of rivaroxaban plus Aspirin® is more efficient (superiority testing) as rivaroxaban alone in the prevention of early venous stent thrombosis in patients suffering from post-thrombotic syndrome in the first 6 months following endovascular therapy To demonstrate tolerability of combination therapy of Aspirin® plus rivaroxaban …

blood clot
  • 03 Jun, 2022
  • 6 locations
Pentoxifylline Dose Optimization in Neonatal Sepsis

Sepsis is a very important cause of death and morbidity in preterm infants. There are strong indications that preterm neonates with sepsis could benefit, next to antibiotics, from treatment with pentoxifylline (PTX). Knowledge about optimal dosing is however limited. This study is a dose optimization study using a step-up and …

blood culture
inflammatory response
  • 14 Jul, 2022
  • 2 locations
Physical Activity in Dialysis: Clinical and Biological Impact

Physical inactivity is known to increase the risk of developing many diseases as cardiovascular diseases, diabetes, some cancers, and other chronic diseases. The impact of the inactivity is even higher in a fragile population as patients with Chronic Renal Failure (CRF) who need dialysis. This can lead to serious adverse …

  • 17 Oct, 2021
  • 2 locations