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Found 336 clinical trials
Featured trial
Non-inferiority study of GSK3511294 compared with mepolizumab or benralizumab in participants with severe asthma with an eosinophilic phenotype

A study for patients with severe asthma currently treated with injectable medication (benralizumab or mepolizumab) to see if the study medication can improve lung function and decrease the frequency of exacerbations of asthma.

  • 0 views
  • 07 Jul, 2022
  • 1 location
Featured trial
Add on treatment for Asthma for patients who experience frequent exacerbations

This is a study involving an add-on injectable medication for asthmatic patients who experience frequent exacerbation of their symptoms, requiring additional medications and/or medical care to treat.

  • 0 views
  • 13 Jul, 2022
  • 1 location
A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for the Treatment of Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients (IMAGINE)

This trial investigates the efficacy and safety of clazakizumab [an anti-interleukin (IL)-6 monoclonal antibody (mAb)] for the treatment of CABMR in recipients of a kidney transplant.

  • 142 views
  • 20 Sep, 2022
  • 51 locations
A Phase 2b Pivotal Study to Evaluate the Efficacy and Safety of Izokibep in Subjects With Moderate to Severe Hidradenitis Suppurativa

Izokibep is a potent and selective inhibitor of interleukin 17A (IL-17A) that is being developed for treatment of hidradenitis suppurativa (HS). This study will evaluate the efficacy

interleukin
antiseptics
abscess
antibiotics
  • 29 views
  • 19 Sep, 2022
  • 17 locations
Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery:a Prospective, Multicenter, Double-blind, Randomized Controlled Trial

Title: Effect of electroacupuncture on the incidence of postoperative delirium in elderly patients undergoing the major surgery. Research center: Multicenter The Design of the study: Randomized, double-blind, controlled study The population of the study: Elderly patients(65≤age<90 years),it is planned to select a period/time limit for gastrointestinal tumor surgery, bile duct …

mechanical ventilation
major surgery
orthopedic surgery
postoperative complication
anesthesia
  • 7 views
  • 17 Sep, 2022
  • 1 location
A Phase 4, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease (STAR)

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation.

psoriasis
DMARD
biological drug
spondylitis
apremilast
  • 107 views
  • 18 Sep, 2022
  • 98 locations
A Study of Bermekimab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (LYRA)

The purpose of this study is to evaluate the dose-response of bermekimab efficacy in participants with moderate to severe Hidradenitis Suppurativa (HS).

abscess
adalimumab
  • 170 views
  • 27 Jul, 2022
  • 44 locations
A Phase 3B, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis Who Had an Inadequate Response and/or Intolerance to One Prior Anti-Tumor Necrosis Factor Alpha Agent (SOLSTICE)

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by assessing the reduction in signs and symptoms of PsA.

psoriasis
spondylitis
tumor necrosis factor
tumour necrosis
psoriatic plaque
  • 0 views
  • 20 Sep, 2022
  • 89 locations
Maternal- Fetal Infection (InSPIRe)

The purpose of the protocol is to validate a novel point of care multiplex system to detect and characterize microorganisms responsible for neonatal sepsis, as well as biomarkers of infection, from a simple vaginal sample, in order to improve the prevention of perinatal bacterial infections.

  • 2 views
  • 14 Feb, 2022
  • 3 locations
Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis (MAGiC-ART)

treatments currently used (eg: corticosteroids, methotrexate and TNF-alfa inhibitors). Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine, also referred to as master regulator of the

  • 45 views
  • 17 Feb, 2022
  • 2 locations