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Found 196 clinical trials
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A Phase Ii, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Ro4602522 Added To The Background Therapy Of The Acetylcholinesterase Inhibitors Donepezil Or Rivastigmine In Patients With Moderate Severity Alzheimer's Disease

A Phase Ii, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Ro4602522 Added To The Background Therapy Of The Acetylcholinesterase Inhibitors Donepezil Or Rivastigmine In Patients With Moderate Severity Alzheimer's Disease

  • 64 views
  • 25 Mar, 2021
  • 1 location
Evaluation of Parent Intervention for Challenging Behaviour in Children With Intellectual Disabilities (EPICC-ID)

Children with intellectual disabilities are likely to present with challenging behaviour. Parent mediated interventions have shown utility in influencing child behaviour, although there is a

  • 35 views
  • 23 Jan, 2021
  • 2 locations
Tolerability and Efficacy of L-Serine in Patients With GRIN-related Encephalopathy

a subtype of paediatric encephalopathies leading to intellectual disability, hypotonia, communication deficits and motor impairment (Orphanet entries: 178469, 289266, 101685, for GRIN1, GRIN2A and

  • 0 views
  • 27 Jan, 2021
  • 1 location
Phenylalanine and Its Impact on Cognition

The PICO-Study is a randomized, placebo-controlled, crossover, non-inferiority trial conducted to add evidence to the current European treatment guidelines for adult patients with phenylketonuria.

phenylalanine
neonatal screening
  • 8 views
  • 26 Jan, 2021
  • 1 location
Evaluation of a Treatment With Allopurinol in Adenylosuccinate Lyase Deficiency

The aim of this study is to evaluate the effectiveness of allopurinol treatment at 12 months on the adaptive and cognitive functioning of patients with adenylosuccinate lyase deficiency (ADSL). The psychiatric evaluation will involve the use of standardized tools prior to initiation of treatment, and will be repeated 6 months …

  • 0 views
  • 26 Jan, 2021
  • 2 locations
Tortle Midliner and Intraventricular Hemorrhage

The purpose of the study is to determine if early application of the Tortle Midliner for preterm infants, 3 hours following birth and with subsequent continuous use through 72 hrs. of life to ensure maintenance of optimal midline positioning (Tortle group), will impact the IVH outcome as determined by a …

  • 13 views
  • 23 Jan, 2021
  • 1 location
Nutritional Interventions in Peritoneal Dialysis Patients With Hypoalbuminemia

Inadequate dietary protein intake is well-known cause of hypoalbuminemia in dialysis population. Protein loss into dialysate and increased catabolic state due to uremic milieu or inflammation worsened hypoalbuminemia, hence high protein diet is recommended in patients on peritoneal dialysis (PD). The recommendations from K/DOQI clinical practice guidelines for the amount …

  • 0 views
  • 14 Feb, 2021
  • 1 location
Decreasing Risk of Psychosis by Sulforaphane (DROPS Trial)

This is a randomized, double-blind, placebo-controlled, multi-centre trial. A total of 300 CHR subjects will be identified in the course of face-to-face interviews using the Structured Interview for Prodromal Syndromes. All participants will be randomly allocated to SFN group (n = 150) or placebo group (n = 150). The study …

  • 1 views
  • 25 Jan, 2021
  • 11 locations
Genome Sequencing Strategies for Genetics Diagnosis of Patients With Intellectual Disability

Introduction : Intellectual Disability (ID) is the most common cause of referral in the pediatric genetic centers and is characterized by an extreme genetic heterogeneity corresponding to a

  • 0 views
  • 24 Jan, 2021
  • 10 locations
Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic

The primary goal of this project is to identify the best messaging and implementation strategies to maximize SARS-CoV-2 testing for children with intellectual and developmental disabilities (IDD) and their teachers to help ensure a safe school environment. Additionally, we will understand nationally the perceptions of COVID-19 and identify facilitators and …

  • 0 views
  • 26 Jan, 2021
  • 3 locations