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Found 44 clinical trials
Featured trial
A trial evaluating TEPEZZA® in Patients With Diffuse Cutaneous Systemic Sclerosis (dcSSc)

The overall objective is to investigate the safety, tolerability and effect on insulin-like growth factor-1 (IGF-1), inflammatory and fibrotic biomarkers of TEPEZZA® administered once every 3

  • 20 May, 2022
  • 3 locations
Bone Graft Cultivation by Periosteal Elevation

growth factor-2(FGF2), Transforming Growth Factor(TGFB1), and Insulin-like growth factor(IGF1)) assessment will be done as well

  • 11 Apr, 2022
Protein Delivery in Intermittent and Continuous Enteral Nutrition in ICU Patients (ProBoNo)

and densitiy of the hamstrings assessed by ultrasound and histology, the process of gastric residual volume, number of diarrhoea events and laboratory findings like glucose, urea and insulin like

Accepts healthy volunteers
  • 02 Jul, 2022
  • 1 location
Achilles Tendinopathy Shear Wave Elastography Study

The purpose of this prospective study is to utilize a real-time ultrasound modality known as real-time Shear Wave Elastography (SWE) to first study the viscoelastic properties of the Achilles tendon to understand the functional differences between normal/asymptomatic vs tendinotic/symptomatic tendon states. The secondary aim will be to assess the degree …

  • 27 Feb, 2022
  • 1 location
Biomarker-guided Intervention to Prevent Acute Kidney Injury

There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury. The investigators hypothesize that the implementation of a bundle of supportive measures adapted to patients undergoing major non-cardiac surgery reduces the occurrence of AKI. …

  • 28 Dec, 2021
  • 7 locations
ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer (ABCSG C08)

ABCSG C08 is a randomized, two-arm, multicenter trial to investigate the efficacy of endurance exercise following adjuvant chemotherapy in patients with colorectal cancer. Indication: Locally advanced colorectal cancer after adjuvant chemotherapy. Evidence supporting the beneficial effects of exercise programs during chemotherapy are available, the results across studies are not entirely …

adjuvant chemotherapy
adenocarcinoma of colon
  • 06 Jun, 2022
  • 8 locations
A Pilot Treatment Study of Insulin-Like Growth Factor-1 (IGF-1) in Autism Spectrum Disorder

The proposed project will pilot the use of IGF-1 as a novel treatment for core symptoms of autism. We will use a double-blind, placebo-controlled crossover trial design in five children with autism to evaluate the impact of IGF-1 treatment on autism-specific impairments in socialization, language, and repetitive behaviors. We expect …

pervasive developmental disorder
  • 28 Jul, 2022
  • 1 location
Chinese Medicine WT for Spinocerebellar Ataxia Type 3

effective treatment or palliative methods for patients in the present days. However, low-dose growth hormone, or its downstream product, insulin-like growth factor I (IGF-1), may deter the progress of SCA3

  • 01 Nov, 2021
  • 1 location
Gene Expression Changes In Young and Geriatric Skin

young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult

Accepts healthy volunteers
  • 07 Apr, 2022
  • 1 location
A Pilot Study of Empagliflozin in the Treatment of Acromegalic Cardiomyopathy

Acromegaly is a disease characterized by excess growth hormone(GH) and insulin like growth factor(IGF)-1. Pituitary GH secreting adenoma is the major cause of acromegaly. Acromegalic

growth factor
insulin-like growth factor
heart failure
  • 25 Jan, 2021
  • 1 location