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Found 1237 clinical trials
Evaluating the Metabolic Effects of Dietary NItrate Supplementation for Improving Skeletal Muscle Mitochondrial Function, Insulin Sensitivity, Insulin Secretion, Body Fat Composition and Overall Health (NIMMI)

mostly explored in healthy/obese subjects, for improving blood pressure, endothelial function, insulin response and vascular effects. However, the metabolic effects of dietary nitrate for improving

Accepts healthy volunteers
  • 0 views
  • 21 Oct, 2022
  • 1 location
Investigation of Urinary Biomarkers for the Diagnosis of Insulin Resistance (BIOMUIR)

The study aims at the identification and the quantification of urinary branched-chain amino acids (BCAAs) by mass spectometry in healthy subjects and patients with insulin resistance and

Accepts healthy volunteers
  • 0 views
  • 03 Mar, 2022
  • 1 location
Sleep, Insulin Sensitivity, and Weight in Adolescents Post-bariatric Surgery

Assessing sleep and circadian health in severely obese adolescents undergoing bariatric surgery and examine relation to health outcomes including insulin sensitivity and percent weight loss to

Accepts healthy volunteers
  • 0 views
  • 21 Feb, 2022
  • 1 location
Diluted Insulin in Young Children: Bigger Volumes for Smaller Patients

The aim of this study is to compare the pharmacokinetic (PK) profile of diluted insulin aspart (U25) with undiluted insulin aspart (U100) in school-aged children and adolescents with type 1

  • 6 views
  • 06 Jun, 2022
  • 1 location
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity

High rates of de novo lipogenesis (DNL) and high saturated fatty acid (SFA) fraction in the liver both have been associated with poor metabolic health and hepatic insulin resistance

Accepts healthy volunteers
  • 0 views
  • 28 Nov, 2021
  • 1 location
Effect of Weight Loss on Brain Insulin Sensitivity in Humans

Obesity if known to be associated with brain insulin resistance in humans. This condition has not only implication for the brain but also for whole-body energy homeostasis. Research in rodents

Accepts healthy volunteers
  • 90 views
  • 09 Apr, 2022
  • 1 location
Efficacy of Closed-loop Insulin Therapy in Adults Prone to Hypoglycemia

This study is a RCT of 3 month at home comparing closed-loop control (CLC) system vs sensor and pump therapy (S&P), with a 3-month extension phase, in Type 1 diabetic patient prone to hypoglycemia. After a 2-week run-in phase with blinded CGM, patients who spent 5% or more time below …

  • 0 views
  • 22 Dec, 2021
  • 1 location
Novel Approaches to Enhance Insulin-sensitizing Effects of Exercise: Targeting PAHSA Metabolism (ETAPA)

the family of palmitic acid esters of hydroxy fatty acids (PAHSA), which have anti-inflammatory and insulin-sensitizing properties. We have recently shown that 4 months of exercise training increases

Accepts healthy volunteers
  • 0 views
  • 25 Oct, 2022
  • 1 location
Comparison of Meal-Time Dosing of Insulin in Cystic Fibrosis Related Diabetes

The aim of this study is to assess the utility of CGMs to determine the optimal method to dose meal-time insulin. The investigators will examine glucose excursions in patients with CF who will

  • 13 views
  • 07 Oct, 2022
  • 1 location
Effect of Preoperative Carbohydrate Loading on Post-operative Insulin Resistance After Donor Hepatectomy.

It's a randomized control trial to compare the effect of preoperative carbohydrate loading versus fasting on post operative insulin resistance after donor hepatectomy in terms of donor outcomes

Accepts healthy volunteers
  • 0 views
  • 07 Apr, 2022
  • 1 location