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Found 247 clinical trials
Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy

the effects of REGN4461 on insulin sensitivity, to evaluate the safety and tolerability of REGN4461 and to evaluate the pharmacokinetics (PK) and immunogenicity of REGN4461.

  • 147 views
  • 25 Feb, 2022
  • 7 locations
mTOR as Mediator of Insulin Sensitivity Study

The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. This will be investigated in young healthy male

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
Effect of Weight Loss on Brain Insulin Sensitivity in Humans

indicates that weight loss is able to improve insulin sensitivity of the brain. The current project will test this hypothesis in humans. Therefore, brain insulin sensitivity will be assessed by fMRI in

Accepts healthy volunteers
  • 70 views
  • 09 Apr, 2022
  • 1 location
Sleep, Insulin Sensitivity, and Weight in Adolescents Post-bariatric Surgery

Assessing sleep and circadian health in severely obese adolescents undergoing bariatric surgery and examine relation to health outcomes including insulin sensitivity and percent weight loss to

Accepts healthy volunteers
  • 0 views
  • 21 Feb, 2022
  • 1 location
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity

this end, 18 overweight/obese, but otherwise healthy, males and females will take part in the randomized dietary interventions. The primary outcome is hepatic insulin sensitivity (suppression of EGP

Accepts healthy volunteers
  • 0 views
  • 28 Nov, 2021
  • 1 location
Effect of Physiologic Hyperglucogonemia on Adipocyte Metabolism (Glucagon)

insulin/glucose to test for insulin sensitivity. Clinical Relevance: The results of this study will help the study team to further understand the pathophysiology of metabolic disturbances that is

Accepts healthy volunteers
  • 3 views
  • 01 Mar, 2022
  • 2 locations
Effect of Gender Affirming Hormone Therapy on Glucose Metabolism

The study will test: whether estrogen treatment in transwomen is associated with improved insulin sensitivity and beta cell function whether testosterone treatment in

Accepts healthy volunteers
  • 18 views
  • 23 Mar, 2022
  • 1 location
Forearm Immobilization Metabolic Health and Nutrition

The present study will investigate the impact of dietary branched chain amino acid restriction on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm

  • 0 views
  • 22 Jul, 2021
  • 1 location
Adipose Tissue Dysfunction in Type 2 Diabetes and Its Reversibility by Bariatric Surgery (ADIDYS)

clarified. Hypothesis/aims: To test the hypotheses 1) that T2D is associated with exaggerated AT dysfunction compared with obesity alone, 2) that increased insulin sensitivity and remission of T2D

  • 0 views
  • 11 Apr, 2022
Acute Response to Exercise in Patients With Rheumatoid Arthritis

biological IL-6 blocking agents and exercise on metabolic responses, such as insulin sensitivity and glucose uptake, in patients with RA. To answer this question, adult women diagnosed with RA and healthy

tumour necrosis
edema
tumor necrosis factor
tocilizumab
  • 0 views
  • 04 Sep, 2021
  • 1 location