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Found 87 clinical trials
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

FaR-RMS is an over-arching study for children and adults with newly diagnosed and relapsed rhabdomyosarcoma (RMS)

  • 20 views
  • 26 Jan, 2021
  • 2 locations
Intermittent Selumetinib for Uveal Melanoma

The purpose of this study is to find out what effects, good and/or bad, intermittent dosing of the drug Selumetinib will have on subjects with uveal melanoma. Selumetinib is a drug that blocks (or turns off) methyl ethyl ketone (MEK), a protein activated in some uveal melanoma cells. Selumetinib is …

karnofsky performance status
measurable disease
neutrophil count
cancer
mek inhibitor
  • 4 views
  • 26 Jan, 2022
  • 3 locations
Feasibility of Individualized Therapy for Recurrent GBM

The current study will test the ability and likelihood of successfully implementing individualized combination treatment recommendations for adult patients with surgically-resectable recurrent glioblastoma in a timely fashion. Collected tumor tissue and blood will be examined using a new diagnostic testing called University of California, San Francisco (UCSF) 500 Cancer Gene …

neutrophil count
cancer
glioblastoma multiforme
gliosarcoma
  • 13 views
  • 01 Feb, 2022
  • 1 location
First-line Chemotherapy With Temozolomide Alone for Non-enhancing Adult Brainstem Gliomas With a Diffuse Subtype and Showing Clinical and/or Radiological Infiltrative Pattern of Progression

This phase 2 study is a prospective cohort study. Chemotherapy alone will be proposed to adult patients suffering from a "low grade" brainstem glioma subtype showing infiltrative, non-threatening clinico-radiological progression. Patients will receive temozolomide at a monthly standard dose of 150-200 mg/m2/j J1-J5, will be clinically evaluated every month and …

  • 0 views
  • 19 Sep, 2021
Decompression of Odontogenic Cysts Using an Appliance Fabricated With a Fully Digital Workflow

The aim of this prospective case series is to present clinical results with cystostomy, decompression and final enucleation of odontogenic cysts using a decompression device fabricated with a full digital workflow and delivered on the day of cystostomy. The secondary purpose of our study is to present the volumetric changes …

  • 0 views
  • 10 Mar, 2022
Implementing Circulating Tumor DNA Analysis at Initial Diagnosis to Improve Management of Advanced NSCLC Patients (CIRCULAR)

Multicenter prospective cohort study aiming to evaluate the detection rate of EGFR gene mutation in patients with advanced NSCLC in a real-word clinical setting, based on liquid biopsy and tissue analyses.

lung carcinoma
EGFR
carcinoma
liquid biopsy
  • 0 views
  • 24 Mar, 2022
  • 1 location
A Randomized Placebo Controlled Trial of the Effectiveness of Metformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects

The overall objective of the EMERGE trial is to determine whether metformin + usual care, compared to placebo + usual care (introduced at the time of initial diagnosis of GDM), reduces a) the

metformin
tolerance test
hyperglycemia
diabetes
oral glucose tolerance test
  • 294 views
  • 23 Jan, 2021
  • 3 locations
Systematic Pediatric Assessment of Rome Criteria (SPARC)

, especially with respect to initial diagnosis. Unfortunately, FGIDs are often diagnosed incorrectly by primary care providers, and patients often wait months to years before a correct diagnosis is made, and

  • 0 views
  • 02 May, 2022
  • 1 location
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

determine if acquired resistance to specific agents is related to specific somatic genome variants that are not detected or found in only a minor clone at initial diagnosis. Supportive Care

thioguanine
bortezomib
lymphoid leukemia
residual tumor
cancer
  • 278 views
  • 11 May, 2022
  • 7 locations
STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

The study is a prospective phase II randomised, double-blind, placebo-controlled investigator-driven trial in acute intracerebral haemorrhage patients. The study has 2 arms with 1:1 randomisation to either intravenous tranexamic acid or placebo and will test the hypothesis that in patients with spontaneous ICH, treatment with tranexamic acid within 2 hours …

intracranial hemorrhage
hematoma
stroke
  • 25 views
  • 20 Apr, 2022
  • 24 locations