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Found 377 clinical trials
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally. This is an effectiveness trial - some elements of the trial are deliberately left to the perioperative clinicians' discretion in order to reflect usual practice and maximise generalisability.

  • 0 views
  • 28 Jan, 2021
  • 1 location
Non-ischemic Preservation of the Donor Heart in Heart Transplantation - a Randomized, Controlled, Multicenter Trial

The study intends to compare standard ischemic cold static storage (ICSS) of retrieved hearts intended to be transplanted, to non-ischemic heart preservation (NIHP) in a randomized clinical multicentre trial. The primary hypothesis is that the non-ischemic hypothermic cardioplegic preservation (NIHP) is safe and superior to ischemic cold static storage (ICSS) …

heart transplant
heart disease
lupus
coagulopathy
heart transplantation
  • 0 views
  • 18 Sep, 2022
  • 10 locations
Immuno-Genetic, Inflammation, Retro-Virus, Environment (I-Give)

Immunology combined to neurobiology now offer prominent tools to yield biomarkers, so far missing in psychiatry, and to design innovative treatment approaches based on the discovery of new molecular and cellular targets. As Bipolar Disorder and Schizophrenia are now known to be significantly associated with neuro-inflammation, the project I-GIVE will …

psychiatric disorder
bipolar disorder
psychosis
schizophrenia
Accepts healthy volunteers
  • 52 views
  • 11 Aug, 2022
  • 5 locations
A Clinical Study to Evaluate the Long-Term Safety Sodium Oligomannate Capsules (GV-971)

A clinical study to evaluate the long-term safety of Sodium Oligomannate Capsules (GV-971)

  • 0 views
  • 25 Jan, 2022
  • 43 locations
Remimazolam and Postoperative Nausea and Vomiting in High-risk Patients

This trial aims to explore whether the intraoperative use of remimazolam can reduce the incidence of postoperative nausea and vomiting (PONV) in high-risk patients. According to the Apfel's simplified score, patients with 3 or more of the following factors are at high risk of postoperative nausea and vomiting (PONV), i.e., …

nausea
anesthesia
  • 2 views
  • 19 Jul, 2021
  • 10 locations
Combined Cryotherapy With Compression Versus Cryotherapy Alone After Orthopaedic Surgery

Cryotherapy has been used to enhance recovery after orthopaedic surgery. Many devices are available but few can guarantee a temperature regulation during a prolonged time and therefore have been criticized. The arrival of new advanced cryotherapy devices made it possible to test the effect of prolonged cooling on rehabilitation after …

  • 0 views
  • 26 Apr, 2022
  • 1 location
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis

The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment of TBM. The investigators will conduct a LTA4H genotype stratified, parallel group, randomised, double blind, placebo-controlled multi-centre Phase III non-inferiority trial …

rifampin
meningitis
isoniazid
tuberculosis treatment
corticosteroids
  • 53 views
  • 28 Apr, 2022
  • 1 location
Closed or Open Abdomen for the Management of Abdominal Sepsis

This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED); or B) leave the fascia open after laparotomy and apply a temporary abdominal closure (TAC) device (OPEN) with a vacuum drain. Although debatable, …

laparotomy
sepsis
clinical decision making
  • 2 views
  • 21 Mar, 2022
  • 1 location
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery (GLORIOUS)

Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects of the glucagon-like-peptide-1 (GLP-1) agonist Exenatide versus placebo and restrictive versus liberal oxygenation during …

heart disease
ischemic heart disease
aortic valve replacement
byetta
glp-1
  • 40 views
  • 27 Jan, 2022
  • 1 location
Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease (BioVasc)

To test whether immediate complete revascularization is non-inferior to staged (but within six weeks after index procedure) complete revascularization in Patients presenting with ACS, including Non-ST-elevation ACS (NSTEACS) and ST-elevation myocardial infarction (STEMI), with multivessel disease accepted for PCI

myocardial infarction
ischemia
sirolimus
ck-mb
angiography
  • 0 views
  • 12 Feb, 2022
  • 1 location