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Found 376 clinical trials
Diagnosis of Metastatic Tumors on 68Ga-FAPI PET-CT and Radioligand Therapy With 177Lu-EB-FAPI

FAP is a fibroblast activation protein and overexpressed in many tumor tissues. This study is intended to conduct preliminary clinical transformation and internal irradiation dosimetry research on 177Lu-EB-FAPI--a new 177Lu therapeutic drug modified by Evans Blue (EB) for the first time in the world.

  • 15 Jun, 2022
  • 1 location
Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes

The aim of this study is to determine if early and tight restoration of metabolic control at the onset of Type 1 diabetes (T1DM) will improve insulin secretion (C-peptide production) versus routine diabetes management.

  • 07 Nov, 2020
  • 3 locations
Augmenting Standard-of-care Treatment of Plaque Psoriasis by Neuromodulation

The human body responds to inflammation, such as psoriatic skin lesions, by activating the cholinergic anti-inflammatory pathway. In patients with plaque psoriasis, this pathway is not sufficient to clear the skin lesions. Importantly, the vagus nerve, that is part of the anti-inflammatory pathway, also innervates the ear where it can …

  • 12 May, 2022
  • 1 location
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in …

Accepts healthy volunteers
  • 15 Feb, 2022
  • 1 location
Effects of Almond Consumption on Innate and Adaptive Immune System

Almonds are a rich matrix of different nutrients with demonstrated benefits on immune system. This proposal examines the effect of regular consumption of almonds on innate and adaptive immune system in healthy individuals with overweight regularly consuming a Western-style diet and unhealthy snacks.

Accepts healthy volunteers
  • 18 Oct, 2021
  • 1 location
Evaluating the Use of ProKera Plus in the Management of Bacterial Corneal Ulcers

The study design is a prospective, randomized, controlled interventional study to compare the outcome of ProKera Plus with conventional treatment in patients with vision-threatening bacterial corneal ulcers. The study will be conducted at the University of Arkansas Medical Sciences (UAMS) in two phases for patients who present to an Ophthalmology …

  • 11 Dec, 2021
  • 1 location
Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19

Clinical, control, double-blind, randomized trial with tenofovir disoproxyl fumarate and emtricitabine for Covid-19

  • 01 Feb, 2021
  • 1 location
A Food Additive Removal Diet for Pediatric Eosinophilic Esophagitis (FREE)

Prospective, pragmatic standard of care clinical trial comparing dietary therapies of standard dairy elimination diet alone (DED) to dairy elimination plus food additive elimination (FREE)

elimination diet
  • 23 Apr, 2022
  • 2 locations
Anti-inflammatory Actions of Osteopathic Manipulative Treatment (OMT_taVNS)

This study evaluates the hypothesis that osteopathic manipulative treatment (OMT) and non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) elicit anti-inflammatory actions through activation of the parasympathetic nervous system. In a cross-over design, research participants will be subjected to various combinations of OMT, taVNS, or sham interventions during four study sessions, …

Accepts healthy volunteers
  • 23 Mar, 2022
  • 1 location
The IPLA-OVCA Trial, Intra-Peritoneal Local Anaesthetics in Ovarian Cancer (IPLA-OVCA)

Surgery and chemotherapy combined constitute first line treatment in women with advanced ovarian cancer. The aim of surgery apart from staging is cytoreduction, i.e. surgical resection of tumour. Radical resection of all tumour visible by the naked eye followed by adjuvant chemotherapy is associated with best chance of prolonged survival. …

fallopian tube
surgery for ovarian cancer
cancer of the ovary
cytoreductive surgery
  • 11 Jul, 2022
  • 1 location