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Found 144 clinical trials
Featured trial
Dose Ranging Study of Amlitelimab in Adult Participants With Moderate-to-severe Asthma (TIDE-asthma)  

This is a parallel, Phase 2, global, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, four-arms study for treatment. The purpose of this study is to assess the efficacy, safety, and tolerability of add-on therapy with amlitelimab in adult participants with moderate-to-severe asthma. Study details include: The study duration (per participant) will be …

  • 22 views
  • 02 Feb, 2023
  • 5 locations
Featured trial
Dupilumab in CRSsNP (Liberty CRSsNP ORION)  

Primary Objective: Part A and B: To evaluate the efficacy of dupilumab as assessed by the reduction at Week 24 in sinus opacification on computerized tomography (CT) scan and sinus total symptom score (sTSS) compared to placebo Secondary Objectives: Part A To evaluate the efficacy of dupilumab as assessed by …

ct scan
sinusitis
congestion
sinus surgery
asthma
  • 20 views
  • 31 Jan, 2023
  • 8 locations
Featured trial
A Phase III, randomized, double-blind, placebo-controlled trial in patients with Ankylosing Spondylitis (AS).

A Phase III, randomized, double-blind, placebo-controlled trial in patients with Ankylosing Spondylitis (AS).

  • 1640 views
  • 08 Nov, 2020
  • 1 location
Featured trial
Rheumatoid arthritis can affect your daily life, don't let it win! Learn more about a new research study now enrolling.

Rheumatoid arthritis can affect your daily life, don't let it win! Learn more about a new research study now enrolling.

  • 1121 views
  • 23 Nov, 2020
  • 1 location
A Phase 3B, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis Who Had an Inadequate Response and/or Intolerance to One Prior Anti-Tumor Necrosis Factor Alpha Agent (SOLSTICE)

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by assessing the reduction in signs and symptoms of PsA.

psoriasis
peripheral arthritis
rheumatoid nodules
tumour necrosis
tumor necrosis factor
  • 0 views
  • 25 Oct, 2022
  • 87 locations
A Pragmatic Trial to Evaluate the Intermediate-term Effects of Early, Aggressive Versus Escalation Therapy in People With Multiple Sclerosis (TREAT-MS)

FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other …

  • 425 views
  • 20 Oct, 2022
  • 41 locations
Efficacy of Artemisia Pollen Specific Allergen Immunotherapy

Allergic rhinitis (AR) is a noninfectious inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) after exposure to allergens. Artemisia annua is one of the most important

  • 0 views
  • 04 Jun, 2022
Dental Hygiene and Peri-Implant Tissues Homeostasis Ancillary Study

Peri-implantitis is an inflammatory disease that leads to loss of jawbone around dental implants. Recent discoveries have identified increased release of Titanium (Ti) particles around implants

osteopenia
Accepts healthy volunteers
debridement
  • 1 views
  • 02 Feb, 2022
  • 1 location
Methotrexate in Patients With Early Rheumatoid Arthritis (MTXRA)

Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting the small joints of hands and feet, but may also present with systemic, extraarticular features. The Swedish

methotrexate
corticosteroids
antirheumatics
  • 0 views
  • 04 Oct, 2022
  • 3 locations
Rotation or Change of Biotherapy After TNF Blocker Treatment Failure for Axial Spondyloarthritis (ROC-SPA)

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by inflammatory arthritis and enthesitis involving the spine. AxSpA prevalence is around 0.17% of the French

rheumatoid arthritis
anti-rheumatic drugs
NSAID
adalimumab
golimumab
  • 17 views
  • 28 Oct, 2022
  • 13 locations