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Found 41 clinical trials
A Phase 2 Multicenter, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Safety and Efficacy of Lutikizumab (ABT-981) in Adult Subjects With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease which includes the forming of lumps, abscesses and scars in areas of the skin such as under the breasts

abscess
  • 46 views
  • 22 Sep, 2022
  • 45 locations
A Study of Bermekimab for the Treatment of Participants With Moderate to Severe Hidradenitis Suppurativa (LYRA)

The purpose of this study is to evaluate the dose-response of bermekimab efficacy in participants with moderate to severe Hidradenitis Suppurativa (HS).

adalimumab
abscess
  • 170 views
  • 27 Jul, 2022
  • 44 locations
Predicting Inflammatory Skin Disease Response to IL-23 Blockade

This study examines the effect of IL-23 blockade with Tildrakizumab on the immune cells of psoriatic skin lesions.

  • 0 views
  • 16 Jun, 2022
  • 1 location
Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.

Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one

Accepts healthy volunteers
  • 0 views
  • 27 Apr, 2022
  • 1 location
A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome

In this phase I/II trial a topical skin cream with the active substance SXR1096 will be tested in patients with Netherton syndroms, a rare inflammatory skin disease. SXR1096 is a specific and

  • 0 views
  • 24 Mar, 2022
  • 1 location
Study of Dupilumab to Demonstrate Efficacy in Subjects With Nummular Eczema

Nummular eczema (NE) is an idiopathic chronic inflammatory skin disease that occurs throughout all life periods. Diagnosis is made primarily clinically in correlation with histological findings

  • 0 views
  • 29 Mar, 2021
  • 1 location
Clinical Trial of Probiotic Supplementation in Psoriasis Vulgaris

Psoriasis is a chronic inflammatory skin disease (chronic and recurrent) which is influenced by various factors, namely genetics, immunological processes, and environmental triggers such as

Accepts healthy volunteers
  • 0 views
  • 10 Mar, 2022
  • 1 location
Alternation in the Human Microbiome With Commonly Used Topical Medications

The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients. The specific aims are as follows: Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations …

Accepts healthy volunteers
  • 128 views
  • 30 Jun, 2022
  • 1 location
Non-invasive Photoacoustic Imaging of Skin Inflammatory Disorders With Machine Learning-assisted Scoring

Inflammatory skin disorders are usually assessed by disease scoring system such as Scoring AD (SCORAD)/Eczema Area and Severity Index (EASI) and Psoriasis Area and Severity Index (PASI) for

eczema
diabetes
dermatitis
plaque psoriasis
Accepts healthy volunteers
  • 4 views
  • 19 Apr, 2022
  • 1 location
Biologics and Blistering - Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation Through Suction Blistering

The purpose of this study is to answer: how do inflammation and anti-inflammatory skin therapies work in the skin? Inflammation is a protective response from the body's immune system to injury

Accepts healthy volunteers
  • 0 views
  • 17 Sep, 2022
  • 1 location