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Found 425 clinical trials
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Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction

The objective of this study is to assess efficacy and safety of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) therapy started post flow restoration but prior to stenting during percutaneous coronary intervention (PCI) compared to standard PCI in the setting of acute ST-segment elevation anterior myocardial infarction (STEMI).

  • 0 views
  • 12 Aug, 2021
  • 15 locations
None
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects of the glucagon-like-peptide-1 (GLP-1) agonist Exenatide versus placebo and restrictive versus liberal oxygenation during …

ischemic heart disease
exenatide
aortic valve replacement
heart surgery
arterial disease
  • 36 views
  • 25 Apr, 2021
  • 1 location
None
FLOW Evaluation to Guide Revascularization in Multi-vessel ST-elevation Myocardial Infarction

Although current guidelines recommend fractional flow reserve (FFR) to identify haemodynamically relevant coronary lesion(s) in stable patients when evidence of ischaemia is not available (Class I, Level of Evidence: A), no published study has assessed the usefulness of FFR to guide percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) …

stenosis
percutaneous coronary intervention
coronary artery disease
stemi
angiography
  • 6 views
  • 23 Jan, 2021
  • 1 location
None
Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease

To test whether immediate complete revascularization is non-inferior to staged (but within six weeks after index procedure) complete revascularization in Patients presenting with ACS, including Non-ST-elevation ACS (NSTEACS) and ST-elevation myocardial infarction (STEMI), with multivessel disease accepted for PCI

myocardial infarction
percutaneous coronary intervention
troponin
chest pain
infarct
  • 0 views
  • 25 Jan, 2021
  • 1 location
None
Very Early Versus Delayed Angiography +/- Intervention on Outcomes in Patients With NSTEMI

Prospective, open, multicentre, randomised controlled trial in patients with higher risk non-ST elevation myocardial infarction acute coronary syndrome

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Danish Trial of Beta Blocker Treatment After Myocardial Infarction Without Reduced Ejection Fraction

To determine whether long-term treatment with oral betablocker (BB) therapy after myocardial infarction (MI) in patient with no heart failure reduces the composite outcome of death from any cause, recurrent MI, unstable angina pectoris, stroke or heart failure.

metoprolol
carvedilol
beta blockers
ejection fraction
unstable angina
  • 1 views
  • 23 Jan, 2021
  • 1 location
None
A Polypill for Secondary Prevention of Ischemic Heart Disease

Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. The most important aspect of CVD secondary prevention is adherence to guideline-indicated pharmacological therapy which globally remains low. In previous studies, a Polypill containing fixed dose combination of essential drugs have improved patient adherence to these drugs. The …

metoprolol
beta blockers
heart disease
beta-adrenergic blocking agents
hmg-coa reductase inhibitor
  • 10 views
  • 26 Jan, 2021
  • 2 locations
None
Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART)

Long-term beta-blocker therapy has not been investigated in contemporary randomized clinical trials in patients with myocardial infarction and normal heart function. The aim of this study is to determine whether long-term treatment with oral beta-blockade in patients with myocardial infarction and preserved left ventricular systolic ejection fraction reduces the composite …

metoprolol
beta blockers
ejection fraction
angiography
beta blocker
  • 6 views
  • 25 Jan, 2021
  • 1 location
None
BEtablocker Treatment After Acute Myocardial Infarction in Patients Without Reduced Left Ventricular Systolic Function

The study aims to investigate whether oral betablocker (BB) therapy is superior to no such treatment following an acute myocardial infarction (AMI).

bundle branch block
left bundle branch block
q waves
acute myocardial infarction
angiography
  • 0 views
  • 22 Jan, 2021
  • 5 locations
None
Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI

The RIGHT study is a large randomized study dedicated to post-PPCI anticoagulation in STEMI patients. The investigators propose to evaluate the clinical efficacy and safety of anticoagulation prolonged for at least 48 hours after the procedure vs. no prolongation of anticoagulation after procedure in patients with STEMI treated with bivalirudin …

heparin
stemi
enoxaparin
  • 0 views
  • 01 Feb, 2021
  • 1 location