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Found 429 clinical trials
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Intracoronary Infusion of BM-Derived Mononuclear Cells in Patients With Large Acute Myocardial Infarction

Large acute myocardial infarctions are the most frequent cause of subsequent systolic heart failure. Some evidence exists on the improvement after intracoronary administration of bone marrow cells in patients with a recente acute myocardial infarction. Although subgroup analyses suggest that patients with the largest myocardial infarctions have the largest increase …

heart failure
acute myocardial infarction
  • 8 views
  • 07 Nov, 2020
  • 1 location
None
Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction

This study is a first-in-human assessment of safety of using UCMSC in patients with AMI via a combination of IC and IV stem cell administration. The novelty of the current UMSC01 treatment study is the dual route of administration. Since dual administration of UCMSC via IC and IV had never …

  • 1 views
  • 15 Feb, 2021
  • 1 location
None
Safety Study of Allogeneic Mesenchymal Precursor Cells (MPCs) in Subjects With Recent Acute Myocardial Infarction

Primary Objective The primary objective of this study is to evaluate the safety and feasibility of transendocardial injection using the Cordis Biosense NogaStarTM Mapping Catheter with the Biosense MyostarTM Left Ventricular Injection Catheter of 25 M, 75 M, and 150 M allogeneic mesenchymal precursor cells (MPCs) in subjects with AMI. …

angina pectoris
acute myocardial infarction
stemi
cardiomyopathy
  • 12 views
  • 07 Nov, 2020
  • 1 location
None
Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes

The aim is to expand evidence about the importance of the mediodorsal nucleus of the thalamus as a key node in human higher-order cognitive functions such as learning, decision-making, and adaptive behavior. Thus, the project proposes to assess global cognition along with higher-order cognition integrity via sensitive behavior tasks in …

  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Coronary CT Angiography in Non ST-elevation Myocardial Infarction

Non ST-elevation myocardial infarction (NSTEMI) represents 70-75% of all myocardial infarctions. Current guidelines recommend invasive angiography and this patient group represents a major burden on the invasive catheterization laboratories and the health care system. The coronary pathology found in NSTEMI-patients varies substantially, ranging from structurally normal vessels, non-obstructive atherosclerosis to …

  • 0 views
  • 26 Jan, 2021
  • 8 locations
None
Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation

There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation. It is unknown whether the choice of anesthesia is impacted on the outcomes for these patients or not. The investigators will perform a randomized controlled …

  • 11 views
  • 20 Sep, 2021
  • 1 location
None
Etiologic Mechanisms Myocardial Changes and Prognosis of Patients With MINOCA

This prospective trial will include 150 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). A thorough clinical, laboratory and imaging evaluation will be performed by novel biomarkers and modern imaging techniques (heart magnetic resonance imaging and noninvasive testing). Moreover, two different treatment groups will be distinguished. Additionally, a retrospective …

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
To Evaluate the Efficacy and Safety of Hearticelgram -AMI in Patients With Acute Myocardial Infarction.

Through the injection of Hearticellgram-AMI into acute myocardial infarction patients who are the primary targets of the drug, long term efficacy in the improvement of the left ventricle ejection fraction upon the first cell treatment is to be evaluated and compared with the current existing treatments (contemporary drug treatment). This …

electrocardiogram
ejection fraction
  • 44 views
  • 30 Oct, 2021
  • 10 locations
None
Aspiration Device in Myocardial Infarction Trial

Early promising data are published focusing on the role of manual thrombus aspiration devices in patients with ST segment elevation (STEMI). The aim of our single center randomized study is to evaluate the early and late effect of thrombus aspiration device (AD) after every stage during Primary PCI in the …

  • 0 views
  • 07 Nov, 2020
  • 1 location
None
EXCELLENT (EXpanded CELL ENdocardiac Transplantation)

A multicentric controlled phase I / IIb study evaluating the safety and the efficacy of in vitro expanded peripheral blood CD34+ stem cells output by the StemXpand Automated Process, and injected in patients with an acute myocardial infarction and a LVEF remaining below 50% after reperfusion versus standard of care.

troponin
ejection fraction
coronary angioplasty
  • 0 views
  • 11 Jul, 2021
  • 13 locations